光疗在银屑病中的应用：作用机制的综述。
Phototherapy in psoriasis: a review of mechanisms of action.
机构信息
Department of Dermatology, University of California, San Francisco, CA, USA.
出版信息
J Cutan Med Surg. 2013 Jan-Feb;17(1):6-12. doi: 10.2310/7750.2012.11124.
Abstract
BACKGROUND
Phototherapy is one of the most efficacious treatment options for psoriasis. New, emerging studies are beginning to define the biologic mechanisms by which phototherapy improves psoriasis.
METHODS
To provide an overview of the mechanisms thought to be responsible for the therapeutic effects of phototherapy, a review was performed on all relevant published studies in the Medline database from January 1, 1985, to August 15, 2011.
FINDINGS
Four categories of action were proposed in the literature to describe the effects of phototherapy in psoriasis: (1) alteration of the cytokine profile, (2) induction of apoptosis, (3) promotion of immunosuppression, and (4) all other mechanisms.
CONCLUSIONS
Phototherapy acts through a combination of pathways to confer therapeutic benefits in psoriasis, and these different modalities may help explain its particular usefulness in treating this cutaneous disease.
摘要
背景
光疗是治疗银屑病最有效的方法之一。新出现的研究开始确定光疗改善银屑病的生物学机制。
方法
为了全面了解光疗治疗效果的潜在机制，对 1985 年 1 月 1 日至 2011 年 8 月 15 日 Medline 数据库中所有相关的已发表研究进行了综述。
发现
文献中提出了四类作用机制来描述光疗对银屑病的影响：（1）细胞因子谱的改变，（2）诱导细胞凋亡，（3）促进免疫抑制，（4）其他所有机制。
结论
光疗通过多种途径发挥作用，为银屑病带来治疗益处，这些不同的作用模式可能有助于解释其在治疗这种皮肤疾病方面的特殊作用。
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Keratinocyte apoptosis in epidermal remodeling and clearance of psoriasis induced by UV radiation.表皮重塑和紫外线辐射诱导的银屑病清除过程中的角质形成细胞凋亡。
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Effective narrow-band UVB radiation therapy suppresses the IL-23/IL-17 axis in normalized psoriasis plaques.有效窄谱 UVB 辐射疗法可抑制正常银屑病斑块中的 IL-23/IL-17 轴。
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