[巴西中部地区基于人群的癌症登记处中乳腺癌分期的时间演变]

[Temporal evolution of breast cancer stages in a population-based cancer registry in the Brazilian central region].

作者信息

Martins Edesio, Freitas-Junior Ruffo, Curado Maria Paula, Freitas Nilceana Maya Aires, De Oliveira José Carlos, Silva Carleane Maciel Bandeira E

机构信息

Registro de Câncer de Base Populacional de Goiânia, Associação de Combate ao Câncer em Goiás, Goiânia, GO, Brasil.

出版信息

Rev Bras Ginecol Obstet. 2009 May;31(5):219-23. doi: 10.1590/s0100-72032009000500003.

DOI:10.1590/s0100-72032009000500003

PMID:19669028

Abstract

PURPOSE

To analyze the temporal changes of breast cancer staging at diagnosis among women living in Goiânia, Goiás, Brazil, between 1989 and 2003.

METHODS

Retrospective and descriptive study in which the cases were identified from the Population-Based Cancer Registry of Goiânia for the period from 1989 to 2003. The variables studied were age, diagnostic method, topographic sublocation, morphology and breast cancer staging. Frequency analyses were carried out on the variables and means, and the medians for the age were determined. The SPSS(R) 15.0 software was used for statistical analyses.

RESULTS

A total of 3,204 breast cancer cases were collected. The mean age was 56 years (sd+/-16 years). With regard to clinical staging, 45.6% of the cases were found to be localized in the breast, with an increased rate of 19.25% between the first and the third five-year period (p<0.001; CI 95%=0.14-0.23) and 10.2% of cases were with distant metastases. However, a reduction of 17.74% for metastatic cases in the same interval (p<0.001 e CI 95%=0.14-21) was observed. The in situ case rate was 0.2% in 1989-1993 and increased to 6.2% in 1999-2003 (p<0.001, IC95%=4.9-7.4).

CONCLUSION

The diagnostic profile of breast cancer in the city of Goiânia is changing. Substantial increases in the number of early breast cancer cases are being found in relation to the number of advanced cases.

摘要

目的

分析1989年至2003年期间居住在巴西戈亚斯州戈亚尼亚市的女性乳腺癌诊断分期的时间变化。

方法

进行回顾性描述性研究，从戈亚尼亚市基于人群的癌症登记处识别出1989年至2003年期间的病例。研究的变量包括年龄、诊断方法、地形亚部位、形态和乳腺癌分期。对变量进行频率分析以及均值分析，并确定年龄的中位数。使用SPSS(R) 15.0软件进行统计分析。

结果

共收集到3204例乳腺癌病例。平均年龄为56岁（标准差±16岁）。关于临床分期，45.6%的病例发现局限于乳腺，在第一个和第三个五年期之间增加率为19.25%（p<0.001；95%置信区间=0.14 - 0.23），10.2%的病例有远处转移。然而，在同一时间段内转移病例减少了17.74%（p<0.001，95%置信区间=0.14 - 0.21）。原位癌病例率在1989 - 1993年为0.2%，在1999 - 2003年增加到6.2%（p<0.001，95%置信区间=4.9 - 7.4）。