Gagov S
Acta Physiol Pharmacol Bulg. 1975;3-4:13-21.
In order to throw light on the problems related to the magnitude and the possibility of maintaining pressor response in the case of bilateral carotid occlusion (BCO), acute experiments were carried out on heparinized cats in chloralose-urethane narcosis and spontaneous respiration. The perfusion pressure in a hind leg autoperfused with a roller pump with a constant flow and the arterial blood pressure were recorded electromanometrically. A study was made of the changes taking place under the effect of BCO in the normal animal, in animals in a haemorrhagic state, after pharmacological alpha-adrenergic blockade, haemorrhage after alpha-adrenergic blockade, retransfusion of blood + alpha-adrenergic blocking agent and after local application of 0.01 papaverine. It was established that some of the factors determining the haemodynamic state of the organism, such as: blood volume, arterial pressure, vascular resistance, cardiac output, etc., are of great significance for the realization of the pressor response to BCO, but the haemodynamic state of the animal before the occlusion and the interactions between the abovementioned factors are decisive for the form, magnitude and maintenance of the pressor response in BCO.
为了阐明双侧颈动脉闭塞（BCO）时与升压反应的强度及维持可能性相关的问题，在氯醛糖 - 乌拉坦麻醉且自主呼吸的肝素化猫身上进行了急性实验。用恒流滚压泵自灌注后肢的灌注压力和动脉血压通过电子测压法记录。研究了正常动物、处于出血状态的动物、经药理学α - 肾上腺素能阻滞之后、α - 肾上腺素能阻滞后出血、回输血 + α - 肾上腺素能阻滞剂以及局部应用0.01%罂粟碱后，BCO作用下所发生的变化。结果表明，决定机体血液动力学状态的一些因素，如血容量、动脉压、血管阻力、心输出量等，对于实现对BCO的升压反应具有重要意义，但闭塞前动物的血液动力学状态以及上述因素之间的相互作用对于BCO升压反应的形式、强度及维持起决定性作用。
