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在雌激素预处理的去卵巢大鼠中,对前列腺素E2促进性接受性有反应的间脑部位。

Diencephalic sites responsive to prostaglandin E2 facilitation of sexual receptivity in estrogen-primed ovariectomized rats.

作者信息

Hall N R, Luttge W G

出版信息

Brain Res Bull. 1977 May-Jun;2(3):203-7. doi: 10.1016/0361-9230(77)90039-9.

DOI:10.1016/0361-9230(77)90039-9
PMID:196715
Abstract

Crystalline prostaglandin E2 (PGE2) induced high levels of sexual receptivity when stereotaxically implanted into the antirior-bala hypothalamic and preoptic regions of estrogen-primed, ovariectomized rats. Anterior- as well as medial basal hypothalamic implants of PGE2 induced a significant elevation of rectal body temperature, but had no effect on open-field activity scores. The possibility that PGE2 exerts its facilitatory effects upon sexual receptivity via an LHRH mechanism is discussed.

摘要

当将结晶前列腺素E2(PGE2)立体定位植入到经雌激素预处理的去卵巢大鼠的下丘脑前基底部和视前区时,可诱导出高水平的性接受能力。PGE2植入下丘脑前基底部和内侧基底部均会导致直肠体温显著升高,但对旷场活动评分没有影响。本文讨论了PGE2通过促黄体生成素释放激素(LHRH)机制对性接受能力发挥促进作用的可能性。

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Diencephalic sites responsive to prostaglandin E2 facilitation of sexual receptivity in estrogen-primed ovariectomized rats.在雌激素预处理的去卵巢大鼠中,对前列腺素E2促进性接受性有反应的间脑部位。
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Reduction of lipocalin-type prostaglandin D synthase in the preoptic area of female mice mimics estradiol effects on arousal and sex behavior.雌性小鼠视前区中脂钙蛋白型前列腺素D合成酶的减少模拟了雌二醇对唤醒和性行为的影响。
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