Plezbert Julie A, Burke Jeanmarie R
Associate Professor, Department of Clinical Sciences, New York Chiropractic College.
J Chiropr Med. 2005 Autumn;4(3):152-61. doi: 10.1016/S0899-3467(07)60124-4.
To evaluate the clinical efficacy of Arnica at a high potency (200c), on moderating delayed onset muscle soreness and accompanying symptoms of muscle dysfunction.
Twenty subjects completed a maximal eccentric exercise protocol with the non-dominate elbow flexors to induce delayed onset muscle soreness. Either Arnica or placebo tablets were administered in a random, double- blinded fashion immediately after exercise and at 24 hours and 72 hours after exercise. Before exercise, immediately post-exercise, and at 24, 48, 72, and 96 hours post-exercise, assessments of delayed onset muscle soreness and muscle function included: 1) muscle soreness and functional impairment; 2) maximum voluntary contraction torque; 3) muscle swelling; and 4) range of motion tests to document spontaneous muscle shortening and muscle shortening ability. Blood samples drawn before exercise and at 24, 48, and 96 hours after exercise were used to measure muscle enzymes as indirect indices of muscle damage.
Regardless of the intervention, the extent of delayed onset muscle soreness and elevations in muscle enzymes were similar on the days following the eccentric exercise protocol. The post-exercise time profiles of decreases in maximum voluntary contraction torque and muscle shortening ability and increases in muscle swelling and spontaneous muscle shortening were similar for each treatment intervention.
The results of this study did not substantiate the clinical efficacy of Arnica at a high potency on moderating delayed onset muscle soreness and accompanying symptoms of muscle dysfunction. Despite the findings of this study, future investigations on the clinical efficacy of homeopathic interventions should consider incorporating research strategies that emphasize differential therapeutics for each patient rather than treating a specific disease or symptom complex, such as DOMS, with a single homeopathic remedy.
评估高药力(200c)的山金车对缓解延迟性肌肉酸痛及伴随的肌肉功能障碍症状的临床疗效。
20名受试者对非优势侧肘屈肌进行最大离心运动方案,以诱发延迟性肌肉酸痛。运动后立即以及运动后24小时和72小时,随机、双盲给予山金车或安慰剂片。在运动前、运动后即刻以及运动后24、48、72和96小时,对延迟性肌肉酸痛和肌肉功能的评估包括:1)肌肉酸痛和功能损害;2)最大自主收缩扭矩;3)肌肉肿胀;4)记录自发肌肉缩短和肌肉缩短能力的运动范围测试。运动前以及运动后24、48和96小时采集的血样用于测量肌肉酶,作为肌肉损伤的间接指标。
无论采用何种干预措施,在离心运动方案后的几天内,延迟性肌肉酸痛的程度和肌肉酶升高情况相似。每种治疗干预措施下,运动后最大自主收缩扭矩和肌肉缩短能力下降以及肌肉肿胀和自发肌肉缩短增加的时间变化曲线相似。
本研究结果并未证实高药力山金车对缓解延迟性肌肉酸痛及伴随的肌肉功能障碍症状具有临床疗效。尽管有本研究的结果,但未来关于顺势疗法干预临床疗效的研究应考虑采用强调针对每个患者进行个体化治疗的研究策略,而不是用单一顺势疗法药物治疗特定疾病或症状复合体,如延迟性肌肉酸痛。