Moulder J E, Lo P S, Fischer J J
Cancer Treat Rep. 1977 Aug;61(5):825-33.
Mercaptoethylamine (MEA), dimethylsulfoxide (DMSO), and S-2-(3-aminopropylamino)ethylphosphorothioate (WR-2721) were tested for their protective effects against single and fractionated doses of 250 kv X-rays. Acute and late skin reactions and control of the BA-1112 rhabdomyosarcoma were examined in protected and unprotected WAG/Rij rats. All drugs protected skin in both single and fractionated treatment regimens, with MEA giving the most protection and DMSO the least. DMSO and WR-2721 protected tumors against single doses of radiation, and all three drugs tested protected tumors against fractionated irradiation. As a result, only single-fraction treatments of MEA-protected animals showed therapeutically favorable differential protection.
对巯基乙胺（MEA）、二甲基亚砜（DMSO）和S-2-(3-氨丙基氨基)乙基硫代磷酸酯（WR-2721）进行了测试，以考察它们对单次及分次剂量250千伏X射线的防护效果。在受保护和未受保护的WAG/Rij大鼠中，检查了急性和晚期皮肤反应以及BA-1112横纹肌肉瘤的控制情况。在单次和分次治疗方案中，所有药物均对皮肤有保护作用，其中MEA的保护作用最强，DMSO的保护作用最弱。DMSO和WR-2721对单次辐射剂量的肿瘤有保护作用，所测试的三种药物对分次照射的肿瘤均有保护作用。因此，只有MEA保护动物的单次分割治疗显示出治疗上有利的差异保护作用。
