Martin D F, Moulder J E, Fischer J J
Br J Cancer Suppl. 1980 Apr;4:271-4.
The rat rhabdomyosarcoma BA1112 has a number of features which make it a useful model for the study of tumour response to radiation therapy. It is a transplantable tumour, isologous to an inbred line of WAG/Rij rats and it elicits no demonstrable host immune response. The tumour grows locally at the implantation site and rarely metastasizes. It is known to contain hypoxic cells which reoxygenate during a prolonged course of fractionated radiation therapy. The growth and radiation response characteristics of the tumour have remained stable for over 15 years. A newly developed in vitro assay for tumour cell clonogenicity greatly facilitates the measurement of radiation dose-response curves and the monitoring of cell response following in vivo treatment. The in vivo response of the tumour to fractionated radiation therapy is analysed in terms of cellular response, reoxygenation and cell proliferation.
大鼠横纹肌肉瘤BA1112具有许多特性，使其成为研究肿瘤对放射治疗反应的有用模型。它是一种可移植肿瘤，与WAG/Rij近交系大鼠同源，且不会引发明显的宿主免疫反应。肿瘤在植入部位局部生长，很少发生转移。已知其含有缺氧细胞，这些细胞在长时间的分次放射治疗过程中会重新充氧。该肿瘤的生长和放射反应特性在超过15年的时间里一直保持稳定。一种新开发的肿瘤细胞克隆形成体外检测方法极大地促进了放射剂量反应曲线的测量以及体内治疗后细胞反应的监测。从细胞反应、重新充氧和细胞增殖方面分析了该肿瘤对分次放射治疗的体内反应。
