Venge P, Håkansson L, Peterson C G
Int Arch Allergy Appl Immunol. 1987;82(3-4):333-7. doi: 10.1159/000234219.
The eosinophil granulocyte is a pro-inflammatory cell which in its granules contains an abundance of highly cytotoxic proteins such as eosinophil cationic protein, eosinophil-derived neurotoxin, eosinophil peroxidase, eosinophil protein X and major basic protein. Upon stimulation of the cell, these proteins as well as a number of lipid mediators such as leukotriene C4, prostaglandin and platelet-activating factor are released to the exterior. The molecules which are produced during inflammatory reactions of the allergic type attract eosinophils to the target organ and stimulate them to liberate their products. The physiological meaning of this reaction is probably to combat invading parasites; however, in their absence accumulation and activation of eosinophils may cause disease, and one such disease may be chronic asthma.
嗜酸性粒细胞是一种促炎细胞，其颗粒中含有大量高细胞毒性蛋白，如嗜酸性粒细胞阳离子蛋白、嗜酸性粒细胞衍生神经毒素、嗜酸性粒细胞过氧化物酶、嗜酸性粒细胞蛋白X和主要碱性蛋白。细胞受到刺激后，这些蛋白以及一些脂质介质如白三烯C4、前列腺素和血小板活化因子会释放到细胞外。在过敏性炎症反应中产生的分子会将嗜酸性粒细胞吸引到靶器官，并刺激它们释放其产物。这种反应的生理意义可能是对抗入侵的寄生虫；然而，在没有寄生虫的情况下，嗜酸性粒细胞的积累和活化可能会导致疾病，慢性哮喘就是其中一种疾病。
