Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK.
Aging Cell. 2009 Sep;8(5):607-13. doi: 10.1111/j.1474-9726.2009.00509.x. Epub 2009 Aug 12.
Significant extension of lifespan in important mammalian species is bound to attract the attention not only of the aging research community, but also the media and the wider public. Two recent papers published by Harrison et al. (2009) in Nature and by Colman et al. (2009) in Science report increased longevity of mice fed with rapamycin and of rhesus monkeys undergoing caloric restriction, respectively. These papers have generated considerable debate in the aging community. Here we assess what is new about these findings, how they fit with our knowledge of lifespan extension from other studies and what prospects this new work holds out for improvements in human longevity and human health span.
重要的哺乳动物物种寿命的显著延长，不仅会引起衰老研究界的关注，也会引起媒体和更广泛公众的关注。哈里森等人（2009 年）在《自然》杂志和科尔曼等人（2009 年）在《科学》杂志上发表的两篇最新论文报告了雷帕霉素喂养的小鼠和热量限制的食蟹猴寿命的延长。这些论文在衰老研究界引起了相当大的争论。在这里，我们评估这些发现的新颖之处，它们如何与我们从其他研究中获得的关于延长寿命的知识相吻合，以及这项新工作在提高人类寿命和人类健康跨度方面有哪些前景。
