Public Health Sciences Division (PHSD), International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
Epidemiol Infect. 2010 Mar;138(3):347-52. doi: 10.1017/S0950268809990550. Epub 2009 Aug 14.
During epidemics of cholera in two rural sites (Bakerganj and Mathbaria), a much higher proportion of patients came for treatment with severe dehydration than was seen in previous years. V. cholerae O1 isolated from these patients was found to be El Tor in its phenotype, but its cholera toxin (CT) was determined to be that of classical biotype. Whether the observed higher proportion of severe dehydration produced by the El Tor biotype was due to a shift from El Tor to classical CT or due to other factors is not clear. However, if cholera due to strains with increased severity spread to other areas where treatment facilities are limited, there are likely to be many more cholera deaths.
在两个农村地区（Bakerganj 和 Mathbaria）的霍乱流行期间，前来接受治疗的严重脱水患者比例远远高于往年。从这些患者中分离出的霍乱弧菌 O1 表型为 El Tor，但霍乱毒素 (CT) 被确定为经典生物型。观察到的 El Tor 生物型引起的严重脱水比例较高是由于 El Tor 向经典 CT 的转变，还是由于其他因素尚不清楚。然而，如果更严重的霍乱菌株传播到治疗设施有限的其他地区，可能会有更多的霍乱死亡。
