针对爱泼斯坦-巴尔病毒决定抗原的抗体依赖性细胞毒性（ADCC）。二、通过Fc-Fc受体桥接诱导ADCC。
Antibody-dependent cellular cytotoxicity (ADCC) against Epstein-Barr virus-determined antigens II. Induction of ADCC by FC-FC receptor bridging.
作者信息
Jondal M
出版信息
Clin Exp Immunol. 1977 Jul;29(1):1-10.
Abstract
Four different methods to test antibody-dependent cellular cytotoxicity (ADCC) against Epstein-Barr virus (EBV) determined antigens were analysed. It was found that optimal ADCC was obtained if viral antigens were present during the cytotoxicity reaction and that killing probably was mediated by EBV-related immune-complexes forming Fc-Fc receptor bridges between Fc receptor-bearing effector cells and Fc receptor-bearing target cells. Only lymphoid target cells with a high expression of Fc receptors were found to be susceptible in this particular system.
摘要
分析了四种针对爱泼斯坦-巴尔病毒（EBV）确定抗原检测抗体依赖性细胞毒性（ADCC）的不同方法。发现如果在细胞毒性反应期间存在病毒抗原，则可获得最佳ADCC，并且杀伤可能是由EBV相关免疫复合物介导的，这些复合物在携带Fc受体的效应细胞和携带Fc受体的靶细胞之间形成Fc-Fc受体桥。在这个特定系统中，仅发现具有高Fc受体表达的淋巴样靶细胞是易感的。
相似文献
1
2
3
4
Antibody-dependent cellular cytotoxicity (ADCC) against Epstein-Barr virus-determined membrane antigens. I. Reactivity in sera from normal persons and from patients with acute infectious mononucleosis.针对爱泼斯坦-巴尔病毒决定的膜抗原的抗体依赖性细胞毒性（ADCC）。I. 正常人及急性传染性单核细胞增多症患者血清中的反应性。
Clin Exp Immunol. 1976 Jul;25(1):1-5.
5
6
Antibody-dependent cellular cytotoxicity against murine leukemia viral antigens: studies with human lymphoblastoid cell lines and human peripheral lymphocytes as effector cells comparing rabbit, goat, and mouse antisera.针对鼠白血病病毒抗原的抗体依赖性细胞毒性：以人淋巴母细胞系和人外周淋巴细胞作为效应细胞，比较兔、山羊和小鼠抗血清的研究。
J Immunol. 1977 Sep;119(3):1089-96.
7
8
In vitro cell-mediated cytotoxicity in primary biliary cirrhosis and chronic hepatitis. Dysfunction of spontaneous cell-mediated cytotoxicity in primary biliary cirrhosis.原发性胆汁性肝硬化和慢性肝炎中的体外细胞介导细胞毒性。原发性胆汁性肝硬化中自发细胞介导细胞毒性的功能障碍。
J Clin Invest. 1977 Nov;60(5):1116-28. doi: 10.1172/JCI108863.
9
10
Virus-induced enhancement of lymphocyte-mediated antibody-dependent cytotoxicity (ADCC) in vitro.病毒在体外诱导淋巴细胞介导的抗体依赖性细胞毒性（ADCC）增强。
J Immunol. 1984 Jun;132(6):2760-6.
引用本文的文献
1
Anti-class II antibodies in AIDS patients and AIDS-risk groups.艾滋病患者及艾滋病高危人群中的抗II类抗体。
Immunology. 1987 Dec;62(4):599-604.
本文引用的文献
1
Separation of cells according to surface antigens by the use of antibody-coated columns. Fractionation of cells carrying immunoglobulins and blood group antigen.使用抗体包被的柱子根据表面抗原分离细胞。携带免疫球蛋白和血型抗原的细胞分级分离。
Scand J Immunol. 1972;1(1):75-87. doi: 10.1111/j.1365-3083.1972.tb03737.x.
2
Lymphocyte mediated cytotoxicity in vitro. Induction and inhibition by humoral antibody and nature of effector cells.体外淋巴细胞介导的细胞毒性。体液抗体的诱导和抑制作用以及效应细胞的性质。
Transplant Rev. 1972;13:91-114. doi: 10.1111/j.1600-065x.1972.tb00061.x.
3
Surface markers on human B and T lymphocytes. IV. Distribution of surface markers on resting and blast-transformed lymphocytes.人类B淋巴细胞和T淋巴细胞的表面标志物。IV. 静止淋巴细胞和转化淋巴细胞表面标志物的分布
Scand J Immunol. 1974;3(6):739-47. doi: 10.1111/j.1365-3083.1974.tb01309.x.
4
Concentration of Epstein-Barr virus from cell culture fluids with polyethylene glycol.用聚乙二醇从细胞培养液中浓缩爱泼斯坦-巴尔病毒。
J Gen Virol. 1973 Sep;20(3):391-4. doi: 10.1099/0022-1317-20-3-391.
5
Epstein-Barr virus: transformation, cytopathic changes, and viral antigens in squirrel monkey and marmoset leukocytes.爱泼斯坦-巴尔病毒：松鼠猴和狨猴白细胞中的转化、细胞病变变化及病毒抗原
Proc Natl Acad Sci U S A. 1972 Feb;69(2):383-7. doi: 10.1073/pnas.69.2.383.
6
Host cell macromolecular synthesis in cells containing EBV-induced early antigens, studied by combined immunofluorescence and radioautography.通过联合免疫荧光和放射自显影术研究含有EB病毒诱导早期抗原的细胞中宿主细胞的大分子合成。
Virology. 1971 Jul;45(1):22-9. doi: 10.1016/0042-6822(71)90108-5.
7
Appearance of Epstein-Barr virus-associated antigens in infected Raji cells.
Virology. 1971 Jul;45(1):10-21. doi: 10.1016/0042-6822(71)90107-3.
8
Cloning of immunoglobulin-producing human leukemic and lymphoma cells in long-term cultures.长期培养中产生免疫球蛋白的人白血病和淋巴瘤细胞的克隆
Proc Soc Exp Biol Med. 1967 Jan;124(1):107-11. doi: 10.3181/00379727-124-31677.
9
"Protein A" from S. aureus. I. Pseudo-immune reaction with human gamma-globulin.来自金黄色葡萄球菌的“蛋白A”。I. 与人γ-球蛋白的假免疫反应。
J Immunol. 1966 Dec;97(6):822-7.
10
Sensitivity of Epstein-Barr virus (EBV) producer and non-producer human lymphoblastoid cell lines to superinfection with EB-virus.爱泼斯坦-巴尔病毒（EBV）产生细胞系和非产生细胞系的人淋巴母细胞系对EB病毒重叠感染的敏感性。
Int J Cancer. 1972 Jul 15;10(1):44-57. doi: 10.1002/ijc.2910100108.
Zotero 插件