针对爱泼斯坦-巴尔病毒决定抗原的抗体依赖性细胞毒性（ADCC）。二、通过Fc-Fc受体桥接诱导ADCC。

Antibody-dependent cellular cytotoxicity (ADCC) against Epstein-Barr virus-determined antigens II. Induction of ADCC by FC-FC receptor bridging.

作者信息

Jondal M

出版信息

Clin Exp Immunol. 1977 Jul;29(1):1-10.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1541038/

Abstract

Four different methods to test antibody-dependent cellular cytotoxicity (ADCC) against Epstein-Barr virus (EBV) determined antigens were analysed. It was found that optimal ADCC was obtained if viral antigens were present during the cytotoxicity reaction and that killing probably was mediated by EBV-related immune-complexes forming Fc-Fc receptor bridges between Fc receptor-bearing effector cells and Fc receptor-bearing target cells. Only lymphoid target cells with a high expression of Fc receptors were found to be susceptible in this particular system.

摘要

分析了四种针对爱泼斯坦-巴尔病毒（EBV）确定抗原检测抗体依赖性细胞毒性（ADCC）的不同方法。发现如果在细胞毒性反应期间存在病毒抗原，则可获得最佳ADCC，并且杀伤可能是由EBV相关免疫复合物介导的，这些复合物在携带Fc受体的效应细胞和携带Fc受体的靶细胞之间形成Fc-Fc受体桥。在这个特定系统中，仅发现具有高Fc受体表达的淋巴样靶细胞是易感的。

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本文引用的文献

1

Separation of cells according to surface antigens by the use of antibody-coated columns. Fractionation of cells carrying immunoglobulins and blood group antigen.

Scand J Immunol. 1972;1(1):75-87. doi: 10.1111/j.1365-3083.1972.tb03737.x.

2

Lymphocyte mediated cytotoxicity in vitro. Induction and inhibition by humoral antibody and nature of effector cells.

Transplant Rev. 1972;13:91-114. doi: 10.1111/j.1600-065x.1972.tb00061.x.

3

Surface markers on human B and T lymphocytes. IV. Distribution of surface markers on resting and blast-transformed lymphocytes.

Scand J Immunol. 1974;3(6):739-47. doi: 10.1111/j.1365-3083.1974.tb01309.x.

4

Concentration of Epstein-Barr virus from cell culture fluids with polyethylene glycol.

J Gen Virol. 1973 Sep;20(3):391-4. doi: 10.1099/0022-1317-20-3-391.

5

Epstein-Barr virus: transformation, cytopathic changes, and viral antigens in squirrel monkey and marmoset leukocytes.

Proc Natl Acad Sci U S A. 1972 Feb;69(2):383-7. doi: 10.1073/pnas.69.2.383.

6

Host cell macromolecular synthesis in cells containing EBV-induced early antigens, studied by combined immunofluorescence and radioautography.

Virology. 1971 Jul;45(1):22-9. doi: 10.1016/0042-6822(71)90108-5.

7

Appearance of Epstein-Barr virus-associated antigens in infected Raji cells.

Virology. 1971 Jul;45(1):10-21. doi: 10.1016/0042-6822(71)90107-3.

8

Cloning of immunoglobulin-producing human leukemic and lymphoma cells in long-term cultures.

Proc Soc Exp Biol Med. 1967 Jan;124(1):107-11. doi: 10.3181/00379727-124-31677.

9

"Protein A" from S. aureus. I. Pseudo-immune reaction with human gamma-globulin.

J Immunol. 1966 Dec;97(6):822-7.

10

Sensitivity of Epstein-Barr virus (EBV) producer and non-producer human lymphoblastoid cell lines to superinfection with EB-virus.

Int J Cancer. 1972 Jul 15;10(1):44-57. doi: 10.1002/ijc.2910100108.

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