School of Dentistry, Madrid Complutense University, 28040 Madrid, Spain.
Med Oral Patol Oral Cir Bucal. 2009 Dec 1;14(12):e680-5. doi: 10.4317/medoral.14.e680.
Periodontal diseases are complex bacteria-induced infections characterised by an inflammatory host response to plaque microbiota and their by-products. Most of these microorganisms have virulence factors capable of causing massive tissue destruction both directly, through tissue invasion and the production of harmful substances, or indirectly, by activation of host defense mechanisms, creating an inflammatory infiltrate of potent catabolic activity that can interfere with normal host defense mechanisms. In response to the aggression, host defense mechanisms activate innate and adaptive immune responses. Our aim is to offer a general overview of the main mechanisms involved in the host response to bacterial aggression in periodontitis, such as lipopolysaccharide receptor CD14, complement system, polymorphonuclear neutrophils, antibodies and immunoglobulins.
牙周病是一种复杂的细菌感染性疾病，其特征是宿主对菌斑微生物及其产物的炎症反应。这些微生物中的大多数都具有毒力因子，能够通过直接侵袭组织和产生有害物质，或间接通过激活宿主防御机制，造成强大的分解代谢活性的炎症浸润，从而导致大量组织破坏，这种浸润可能会干扰正常的宿主防御机制。为了应对这种侵袭，宿主防御机制会激活先天和适应性免疫反应。我们的目的是提供一个关于宿主对牙周炎细菌侵袭反应的主要机制的概述，如脂多糖受体 CD14、补体系统、多形核白细胞、抗体和免疫球蛋白。
