Guerrero Juan Carlos Hernández, Jiménez-Farfán Maria Dolores, Lopez-Salgado Armando, Barker Matthew L, Gerlach Robert W
Universidad Nacional Autónoma de México, Circuito Institutos Sin Número, Mexico City, Mexico.
Am J Dent. 2007 Sep;20 Spec No A:15A-18A.
To evaluate the clinical response of a professional whitening strip system used by a university-based population residing in Mexico City, Mexico.
A randomized, double-blind, placebo-controlled study was conducted to evaluate the safety and efficacy of 6.5% hydrogen peroxide whitening strips used over a 3-week period. A total of 30 volunteer students and staff at the National Autonomous University of México (Mexico City) were randomly assigned to the peroxide or placebo strip groups. Strips were worn for 30 minutes two times a day for 3 weeks. Efficacy was evaluated using digital image analysis to assess change in L* a* b* tooth color, while safety was assessed by oral examination and subject interview.
Relative to placebo, the 6.5% hydrogen peroxide strip group experienced nearly a 4-unit color improvement (Deltab*). Treatment groups differed significantly (P< 0.0001) with respect to yellowness (Deltab*), lightness (DeltaL*) and redness (Deltaa*). Adjusted mean (SE) overall color improvement (DeltaW*) was -4.76 (0.27) for the peroxide strips, compared to the near zero, -0.21 (0.28) for the placebo control. Strip use was well tolerated. Minor, transient tooth sensitivity occurred more frequently in the peroxide group, and overall, no subjects modified or discontinued treatment early because of adverse events.
评估一种专业美白牙贴系统在居住于墨西哥城的墨西哥某大学人群中的临床反应。
开展一项随机、双盲、安慰剂对照研究，以评估使用为期3周的6.5%过氧化氢美白牙贴的安全性和有效性。墨西哥国立自治大学（墨西哥城）的30名志愿者学生和工作人员被随机分配到过氧化氢牙贴组或安慰剂牙贴组。牙贴每天佩戴两次，每次30分钟，共3周。使用数字图像分析评估Lab*牙齿颜色变化来评价疗效，通过口腔检查和受试者访谈评估安全性。
相对于安慰剂，6.5%过氧化氢牙贴组牙齿颜色改善近4个单位（Δb*）。治疗组在黄度（Δb*）、亮度（ΔL*）和红度（Δa*）方面存在显著差异（P<0.0001）。过氧化氢牙贴的校正平均（标准误）总体颜色改善（ΔW*）为-4.76（0.27），而安慰剂对照接近零，为-0.21（0.28）。牙贴使用耐受性良好。过氧化氢组轻微、短暂的牙齿敏感更为常见，总体而言，没有受试者因不良事件提前改变或停止治疗。
