S.A.F.U. Department, Regina Elena Cancer Institute, Rome, Italy.
J Exp Clin Cancer Res. 2009 Aug 14;28(1):114. doi: 10.1186/1756-9966-28-114.
The treatment of soft tissue tumors needs the coordinated adoption of surgery with radiation therapy and eventually, chemotherapy. The radiation therapy (delivered with a linear accelerator) can be preoperative, intraoperative, or postoperative. In selected patients adjuvant brachytherapy can be adopted. The goal of these associations is to achieve tumor control while maximally preserving the normal tissues from side effects. Unfortunately, the occurrence of local and distant complications is still elevated. Electrochemotherapy is a novel technique that combines the administration of anticancer agents to the application of permeabilizing pulses in order to increase the uptake of antitumor molecules. While its use in humans is still confined to the treatment of cutaneous neoplasms or the palliation of skin tumor metastases, in veterinary oncology this approach is rapidly becoming a primary treatment. This review summarizes the recent progresses in preclinical oncology and their possible transfer to humans.
软组织肿瘤的治疗需要协调采用手术联合放疗，最终还需要联合化疗。放疗（采用线性加速器）可以是术前、术中或术后进行。在选择的患者中，可以采用辅助近距离放疗。这些联合治疗的目的是在最大程度地保留正常组织免受副作用的情况下实现肿瘤控制。不幸的是，局部和远处并发症的发生仍然较高。电化疗是一种将抗癌药物给药与透化脉冲应用相结合的新技术，以增加抗肿瘤分子的摄取。虽然它在人类中的应用仍然局限于治疗皮肤肿瘤或缓解皮肤肿瘤转移，但在兽医肿瘤学中，这种方法正在迅速成为主要治疗方法。本文综述了临床前肿瘤学的最新进展及其可能向人类的转移。
