National Institute of Animal Nutrition and Physiology, Bangalore, India.
Br J Nutr. 2009 Dec;102(11):1629-34. doi: 10.1017/S0007114509990869. Epub 2009 Aug 17.
A 3-week-feeding study (1-21 d post-hatch) was conducted to evaluate the efficacy of total curcuminoids (TCMN), as an antioxidant, to ameliorate the adverse effects of aflatoxin B1 (AFB1) in broiler chickens. Turmeric powder (Curcuma longa L.) that contained 2.55 % TCMN was used as a source of TCMN. Six cage replicates of five chicks each were assigned to each of six dietary treatments, which included: basal diet; basal diet supplemented with 444 mg/kg TCMN; basal diet supplemented with 1.0 mg/kg AFB1; basal diet supplemented with 74 mg/kg TCMN and 1.0 mg/kg AFB1; basal diet supplemented with 222 mg/kg TCMN and 1.0 mg/kg AFB1; basal diet supplemented with 444 mg/kg TCMN and 1.0 mg/kg AFB1. The addition of 74 and 222 mg/kg TCMN to the AFB1 diet significantly (P < 0.05) improved weight gain and feed efficiency. Increase (P < 0.05) in relative liver weight in birds fed AFB1 was significantly reduced (P < 0.05) with the addition of 74, 222 and 444 mg/kg TCMN to the AFB1 diet. The inclusion of 222 mg/kg TCMN ameliorated the adverse effects of AFB1 on serum chemistry in terms of total protein, albumin and gamma-glutamyl transferase activity. The decreased antioxidant functions due to AFB1 were also alleviated by the inclusion of 222 mg/kg TCMN. It is concluded that the addition of 222 mg/kg TCMN to the 1.0 mg/kg AFB1 diet demonstrated maximum antioxidant activity against AFB1.
一项为期 3 周的饲养研究（孵化后第 1-21 天）评估了总姜黄素（TCMN）作为抗氧化剂的功效，以改善黄曲霉毒素 B1（AFB1）对肉鸡的不良影响。姜黄粉（姜黄长 L.）含有 2.55%的 TCMN 作为 TCMN 的来源。6 个鸡笼重复，每个笼中有 5 只小鸡，被分配到 6 种日粮处理中，包括：基础日粮；基础日粮添加 444mg/kg TCMN；基础日粮添加 1.0mg/kg AFB1；基础日粮添加 74mg/kg TCMN 和 1.0mg/kg AFB1；基础日粮添加 222mg/kg TCMN 和 1.0mg/kg AFB1；基础日粮添加 444mg/kg TCMN 和 1.0mg/kg AFB1。在 AFB1 日粮中添加 74 和 222mg/kg TCMN 显著（P < 0.05）提高了增重和饲料效率。用 74、222 和 444mg/kg TCMN 喂养 AFB1 的相对肝重增加（P < 0.05）显著降低（P < 0.05）。在 AFB1 日粮中添加 222mg/kg TCMN 可改善 AFB1 对血清化学的不利影响，如总蛋白、白蛋白和γ-谷氨酰转移酶活性。添加 222mg/kg TCMN 还减轻了 AFB1 对抗氧化功能的降低。综上所述，在 1.0mg/kg AFB1 日粮中添加 222mg/kg TCMN 表现出对 AFB1 的最大抗氧化活性。
