Benedetti Francesco, Calabrese Giovanna, Bernasconi Alessandro, Cadioli Marcello, Colombo Cristina, Dallaspezia Sara, Falini Andrea, Radaelli Daniele, Scotti Giuseppe, Smeraldi Enrico
Department of Neuropsychiatric Sciences, Scientific Institute and University Vita-Salute San Raffaele, Milan, Italy.
Psychiatry Res. 2009 Sep 30;173(3):238-42. doi: 10.1016/j.pscychresns.2008.08.004. Epub 2009 Aug 13.
Glutamate is the primary excitatory neurotransmitter of the human brain, and recent findings suggest a role for the glutamatergic system in the pathophysiology and treatment of mood disorders. Single proton magnetic resonance spectroscopy (1H-MRS) was used to study the relative in vivo levels of brain neural metabolites. We evaluated the effect of antidepressant treatments on the relative concentration of unresolved glutamate and glutamine (Glx) with GABA contamination (2.35 ppm peak) using single voxel 1H-MRS at 3.0 Tesla. We studied 19 inpatients (7 males, 12 females) affected by bipolar disorder type I, current depressive episode without psychotic features, before and after 1 week of treatment with repeated total sleep deprivation (TSD) combined with light therapy (LT). Chronobiological treatment caused a significant amelioration in mood levels. Changes in the brain Glx/creatine ratio followed a general trend toward decrease, with individual variability. We observed that the decrease in the Glx/creatine ratio significantly correlated with the improvement of both objective and subjective measures of depression.
谷氨酸是人类大脑主要的兴奋性神经递质，最近的研究结果表明谷氨酸能系统在情绪障碍的病理生理学及治疗中发挥作用。采用单质子磁共振波谱（1H-MRS）研究脑内神经代谢物的相对活体水平。我们在3.0特斯拉磁场下，使用单体素1H-MRS评估抗抑郁治疗对未分辨的谷氨酸和谷氨酰胺（Glx）相对浓度的影响，其中Glx受GABA污染（2.35 ppm峰）。我们研究了19例I型双相情感障碍患者（7例男性，12例女性），这些患者目前处于无精神病性特征的抑郁发作期，在接受重复完全睡眠剥夺（TSD）联合光照疗法（LT）治疗1周前后进行观察。时间生物学治疗使情绪水平得到显著改善。脑内Glx/肌酸比值的变化总体呈下降趋势，但存在个体差异。我们观察到，Glx/肌酸比值的下降与抑郁客观及主观测量指标的改善显著相关。
