Suppr超能文献

与年龄相关的人类囊虫病的感染和传播模式。

Age-related infection and transmission patterns of human cysticercosis.

机构信息

Institute of Tropical Medicine, Animal Health Department, 2000 Antwerp, Belgium.

出版信息

Int J Parasitol. 2010 Jan;40(1):85-90. doi: 10.1016/j.ijpara.2009.07.007. Epub 2009 Aug 14.

Abstract

Neurocysticercosis is recognised as an important but neglected cause of epilepsy in developing countries where the parasite occurs. Data on the transmission dynamics of the parasite in endemic areas are scarce. Individuals living in these areas are likely to be highly exposed to the parasite, but relatively few of them develop active infections. The present study aimed to describe and gain insights into changes in antibody responses and infection patterns related to age and/or gender in a south Ecuadorian rural population by combining antibody and antigen serological data with demographic characteristics. In 25% of the population, antibodies to Taenia solium cysticerci were detected whilst 2.9% had circulating parasite antigens. The proportion of antibody-positive individuals increased significantly until the age of 40years to become stable in older individuals. A rule-based simulation model was developed to explain these variations and to reflect the dynamics of exposure to, and transmission of, the parasite. In contrast, the proportion of people presenting circulating parasite antigens, reflecting an active infection, was significantly higher in people older than 60years. Immunosenescence could explain such an observation since a weaker immune system in the elderly would facilitate the establishment and maintenance of viable cysticerci compared with fully immunocompetent younger individuals. This work points out the role of the immune system in the development of cysticercosis within an exposed population and highlights new essential issues in understanding the transmission dynamics of the parasite, its incidence and the resulting immunological response at a population level.

摘要

脑囊尾蚴病被认为是寄生虫流行地区发生的重要但被忽视的癫痫病因。寄生虫在流行地区的传播动力学数据稀缺。生活在这些地区的人可能会高度暴露于寄生虫,但只有相对较少的人会发展为活动性感染。本研究旨在通过结合抗体和抗原血清学数据与人口统计学特征,描述并深入了解厄瓜多尔南部农村人口中与年龄和/或性别相关的抗体反应和感染模式的变化。在 25%的人群中检测到了对猪带绦虫囊尾蚴的抗体,而 2.9%的人有循环寄生虫抗原。抗体阳性个体的比例在 40 岁之前显著增加,在老年人中变得稳定。建立了一个基于规则的模拟模型来解释这些变化,并反映寄生虫暴露和传播的动态。相比之下,在 60 岁以上的人群中,出现循环寄生虫抗原(反映活动性感染)的比例显著更高。免疫衰老可以解释这种观察结果,因为老年人的免疫系统较弱,与完全免疫功能正常的年轻人相比,更容易建立和维持存活的囊尾蚴。这项工作指出了免疫系统在暴露人群中囊尾蚴病发展中的作用,并强调了在人群水平上理解寄生虫传播动力学、发病率和由此产生的免疫反应的新的重要问题。

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验