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猪带绦虫病/囊虫病的免疫诊断。

Immunodiagnosis of Taenia solium taeniosis/cysticercosis.

机构信息

Animal Health Department, Institute of Tropical Medicine, Antwerp, Belgium.

出版信息

Trends Parasitol. 2010 Mar;26(3):137-44. doi: 10.1016/j.pt.2009.12.008. Epub 2010 Jan 18.

Abstract

Neurocysticercosis, the infection of the central nervous system by larvae of Taenia solium, is a major cause of epilepsy in developing countries. This cestode is a public health problem in most developing countries where pigs are raised and its occurrence is strongly associated with poverty. The development of immunodiagnostic tools has contributed to our knowledge on the importance of this parasite by enabling seroepidemiological surveys and community-based studies to be conducted. Here, we present a comprehensive overview of the various proteins used in antibody detection techniques, as well as the latest developments in antigen detection techniques and serodiagnosis of taeniosis. A critical view on the use of serology in epidemiological studies and clinical control programs is given and future research needs are presented.

摘要

脑囊尾蚴病是由猪带绦虫幼虫感染中枢神经系统引起的,是发展中国家癫痫的主要病因。这种绦虫是大多数发展中国家的一个公共卫生问题,这些国家普遍养猪,其发生与贫困密切相关。免疫诊断工具的发展通过开展血清流行病学调查和基于社区的研究,使我们对这种寄生虫的重要性有了更多的了解。本文全面概述了用于抗体检测技术的各种蛋白质,以及抗原检测技术和带绦虫病血清诊断的最新进展。本文还对血清学在流行病学研究和临床控制项目中的应用进行了批判性的评价,并提出了未来的研究需求。

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