INSERM, UMR915, l'institut du thorax, Nantes, F-44000, France.
J Mol Cell Cardiol. 2010 Jan;48(1):37-44. doi: 10.1016/j.yjmcc.2009.08.005. Epub 2009 Aug 14.
The two components of the cardiac delayed rectifier current have been the subject of numerous studies since firstly described. This current controls the action potential duration and is highly regulated. After identification of the channel subunits underlying IKs, KCNQ1 associated with KCNE1, and IKr, HERG, their involvement in human cardiac channelopathies have provided various models allowing the description of the molecular mechanisms of the KCNQ1 and HERG channels trafficking, activity and regulation. More recently, studies have been focusing on the unveiling of different partners of the pore-forming proteins that contribute to their maturation, trafficking, activity and/or degradation, on one side, and on their respective expression in the heterogeneous cardiac tissue, on the other side. The aim of this review is to report and discuss the major works on IKs and IKr and the most recent ones that help to understand the precise function of these currents in the heart.
自从首次描述以来，心脏延迟整流电流的两个组成部分一直是众多研究的主题。该电流控制动作电位持续时间，并且受到高度调节。在鉴定了 IKs 所依赖的通道亚基、与 KCNE1 相关的 KCNQ1 和 IKr、HERG 之后，它们在人类心脏通道病中的参与提供了各种模型，允许描述 KCNQ1 和 HERG 通道运输、活性和调节的分子机制。最近的研究重点是揭示参与其成熟、运输、活性和/或降解的孔形成蛋白的不同伴侣，一方面，并在异构性心脏组织中分别表达它们。本综述的目的是报告和讨论关于 IKs 和 IKr 的主要工作，以及最近的研究工作，这些研究工作有助于理解这些电流在心脏中的精确功能。
