Pighon Abdolnaser, Paquette Amélie, Barsalani Razieh, Chapados Natalie Ann, Rabasa-Lhoret Rémi, Yasari Siham, Prud'homme Denis, Lavoie Jean-Marc
Department of Kinesiology, University of Montreal, C.P. 6128, Succ. centre-ville, Montreal, Quebec, Canada H3C 3J7.
Maturitas. 2009 Sep 20;64(1):52-7. doi: 10.1016/j.maturitas.2009.07.005. Epub 2009 Aug 15.
The aim of the present study was to investigate the effects of maintaining only one of the two components of a food restriction (FR)+resistance training (RT) regimen on the regain of body weight and fat mass (liver and adipocytes) in ovariectomized (Ovx) rats.
Five week Ovx rats were submitted to a weight loss program consisting of a 26% FR combined with RT (OvxFR+RT) for 8 weeks. RT consisted of climbing a 1.5m vertical grid with a load attached to the tail, 20-40 times with progressively increasing loads 4 times/week. Following this weight loss intervention, OvxFR+RT rats were sub-divided into 3 groups for an additional 5 weeks: 2 groups went back to a normal ad libitum feeding with or without RT and the other group kept only FR.
Combined FR+RT program in Ovx rats led to lower body mass gain, liver triacylglycerol (TAG) levels, and fat mass gain compared to sedentary normally fed Ovx rats (P<0.01). Stopping both FR and RT over a 5 week period resulted in the regain of body weight, intra-abdominal fat pad weight and liver TAG (P<0.01). When only FR was maintained, the regain of body and fat pad weight as well as liver and plasma TAG concentrations was completely prevented. However, when only RT was maintained, regain in the aforementioned parameters was attenuated but not prevented (P<0.05).
It is concluded that following a FR+RT weight loss program, continuation of only RT constitutes an asset to attenuate body weight and fat mass regain in Ovx rats; although the impact is less than the maintaining FR alone. These results suggest that, in post-menopausal women, RT is a positive strategy to reduce body weight and fat mass relapse.
本研究旨在探讨在去卵巢（Ovx）大鼠中，仅维持食物限制（FR）和抗阻训练（RT）方案两者之一对体重及脂肪量（肝脏和脂肪细胞）恢复的影响。
对5周龄的Ovx大鼠进行为期8周的体重减轻计划，该计划包括26%的FR联合RT（OvxFR+RT）。RT包括尾巴上附着重物攀爬1.5米垂直网格，每周4次，每次20-40次，负荷逐渐增加。在这种体重减轻干预之后，OvxFR+RT大鼠被分为3组，再持续5周：2组恢复正常随意进食，一组有RT，另一组没有RT，另一组仅维持FR。
与久坐不动的正常喂养Ovx大鼠相比，Ovx大鼠的FR+RT联合方案导致体重增加、肝脏三酰甘油（TAG）水平和脂肪量增加更低（P<0.01）。在5周内停止FR和RT会导致体重、腹内脂肪垫重量和肝脏TAG恢复（P<0.01）。当仅维持FR时，可完全防止体重、脂肪垫重量以及肝脏和血浆TAG浓度的恢复。然而，当仅维持RT时，上述参数的恢复有所减轻但未被阻止（P<0.05）。
得出的结论是，在FR+RT体重减轻计划之后，仅继续进行RT有助于减轻Ovx大鼠的体重和脂肪量恢复；尽管其影响小于单独维持FR。这些结果表明，对于绝经后女性，RT是减少体重和脂肪量复发的积极策略。
