Corriveau Patrick, Paquette Amélie, Brochu Martin, Prud'homme Denis, Rabasa-Lhoret Remi, Lavoie Jean-Marc
Department of Kinesiology, University of Montreal, C.P. 6128, Succ. centre-ville, Montreal, Québec, Canada H3C 3J7.
Maturitas. 2008 Mar 20;59(3):259-67. doi: 10.1016/j.maturitas.2008.02.005. Epub 2008 Mar 25.
Menopause is associated with increased lipid deposition in the liver and fat accumulation in the abdomen.
The purpose of the present study was to determine the effects of adding a resistance training program (RT) to a restrictive diet (RD) on liver lipid accumulation and abdominal fat depots in ovariectomized (Ovx) rats.
One group of sham-operated and three groups of Ovx rats were compared. Five weeks after surgery, Ovx rats were either submitted to an approximately 25% RD with or without RT for 3 or 8 weeks, while a third group of Ovx rats were fed ad libitum and remained sedentary. The RT program consisted of climbing a 6m vertical metal grill five times a week with an increasing load up to 75% of body weight attached to the tail. The number of repetitions increased from two to four sets of 10 repetitions.
Ovariectomy resulted in significantly higher (P<0.01) body weight, energy intake, intra-abdominal fat depots, plasma leptin levels (P<0.05), and liver triacylglycerol concentrations. All of these responses were (P<0.01) reduced in Ovx rats following the RD with the exception of liver lipid infiltration. The addition of RT to the RD treatment synergistically reduced abdominal fat deposition and plasma-free fatty acid levels. Moreover, liver lipid infiltration was completely prevented by the addition of the RT program. Muscle mass relative to body weight was significantly increased in Ovx-RD-RT compared to all other groups.
It is concluded that RT is an asset to minimize the deleterious effects of ovarian hormone withdrawal on liver lipid accumulation and abdominal fat accumulation in Ovx rats.
绝经与肝脏脂质沉积增加和腹部脂肪堆积有关。
本研究旨在确定在限制饮食（RD）基础上增加抗阻训练计划（RT）对去卵巢（Ovx）大鼠肝脏脂质蓄积和腹部脂肪库的影响。
比较一组假手术大鼠和三组Ovx大鼠。术后5周，Ovx大鼠分别接受约25%的RD，同时进行或不进行RT，持续3周或8周，而第三组Ovx大鼠自由进食且保持久坐。RT计划包括每周5次攀爬6米垂直金属格栅，尾部附加的负荷逐渐增加至体重的75%。重复次数从两组每组10次增加到四组每组10次。
卵巢切除导致体重、能量摄入、腹腔内脂肪库、血浆瘦素水平（P<0.05）和肝脏三酰甘油浓度显著升高（P<0.01）。除肝脏脂质浸润外，RD后所有这些反应在Ovx大鼠中均降低（P<0.01）。在RD治疗中加入RT可协同减少腹部脂肪沉积和血浆游离脂肪酸水平。此外，加入RT计划可完全防止肝脏脂质浸润。与所有其他组相比，Ovx-RD-RT组相对于体重的肌肉量显著增加。
得出结论，RT有助于将卵巢激素撤退对Ovx大鼠肝脏脂质蓄积和腹部脂肪蓄积的有害影响降至最低。
