Department of Physiology, Ribeirao Preto School of Medicine, University of Sao Paulo, Ribeirao Preto 14049-900, Brazil.
Int J Mol Sci. 2024 May 7;25(10):5066. doi: 10.3390/ijms25105066.
Menopause is characterized by a reduction in sex hormones in women and is associated with metabolic changes, including fatty liver and insulin resistance. Lifestyle changes, including a balanced diet and physical exercise, are necessary to prevent these undesirable changes. Strength training (ST) has been widely used because of the muscle and metabolic benefits it provides. Our study aims to evaluate the effects of ST on hepatic steatosis and insulin resistance in ovariectomized mice fed a high-fat diet (HFD) divided into four groups as follows: simulated sedentary surgery (SHAM-SED), trained simulated surgery (SHAM-EXE), sedentary ovariectomy (OVX-SED), and trained ovariectomy (OVX-EXE). They were fed an HFD for 9 weeks. ST was performed thrice a week. ST efficiently reduced body weight and fat percentage and increased lean mass in OVX mice. Furthermore, ST reduced the accumulation of ectopic hepatic lipids, increased AMPK phosphorylation, and inhibited the de novo lipogenesis pathway. OVX-EXE mice also showed a better glycemic profile, associated with greater insulin sensitivity identified by the euglycemic-hyperinsulinemic clamp, and reduced markers of hepatic oxidative stress compared with sedentary animals. Our data support the idea that ST can be indicated as a non-pharmacological treatment approach to mitigate metabolic changes resulting from menopause.
绝经的特征是女性性激素减少，与代谢变化有关，包括脂肪肝和胰岛素抵抗。生活方式的改变，包括均衡的饮食和体育锻炼，是预防这些不良变化所必需的。力量训练（ST）因其提供的肌肉和代谢益处而被广泛应用。我们的研究旨在评估 ST 对高脂饮食（HFD）喂养的去卵巢小鼠肝脂肪变性和胰岛素抵抗的影响，将其分为以下四组：模拟久坐手术（SHAM-SED）、训练模拟手术（SHAM-EXE）、久坐去卵巢（OVX-SED）和训练去卵巢（OVX-EXE）。它们接受 HFD 喂养 9 周。每周进行 3 次 ST。ST 有效地降低了 OVX 小鼠的体重和体脂百分比，增加了瘦体重。此外，ST 减少了异位肝脂质的积累，增加了 AMPK 磷酸化，并抑制了从头脂肪生成途径。与久坐动物相比，OVX-EXE 小鼠的血糖谱更好，表现出更高的胰岛素敏感性，这可以通过正糖高胰岛素钳夹试验来识别，并且肝氧化应激标志物减少。我们的数据支持这样一种观点，即 ST 可以作为一种非药物治疗方法，用于减轻绝经引起的代谢变化。
