Verbrugghe Peter, Meuris Bart, Flameng Willem, Herijgers Paul
Department of Cardiac Surgery, Katholieke Universiteit Leuven, Leuven, Belgium.
Interact Cardiovasc Thorac Surg. 2009 Nov;9(5):775-9. doi: 10.1510/icvts.2008.200097. Epub 2009 Aug 14.
Repair of complex valve pathological processes often requires the use of leaflet tissue or pericardium. The use of bovine photo-oxidized pericardium may be an alternative, a tissue less prone to calcification. The aim of this study is to evaluate the use of photo-oxidized bovine pericardial tissue in the reconstruction of atrioventricular valves in humans. Between July 2001 and September 2006, 21 patients with complex valve pathology underwent a reconstruction with photo-oxidized pericardium. The pericardial patch was used for the reconstruction of a tricuspid valve leaflet in two patients, the reconstruction of a mitral valve leaflet in six patients, the reconstruction of the tricuspid annulus in one patient and the reconstruction of the mitral annulus in 12 patients. The follow-up ranged from 13.9 to 43.2 months. There were five perioperative deaths. Four patients developed failure of the reconstruction, in one patient there was thinning and perforation of the pericardial patch without signs of infection or abrasion. The other patients were free from thromboembolism, endocarditis, hemorrhagic complications or echocardiographic signs of failure of the reconstruction. Photo-oxidized bovine pericardium is a versatile material for complex reconstruction of the atrioventricular valvular structures. Its durability should, however, be investigated in comparison with alternative tissues in a randomized trial.
复杂瓣膜病理过程的修复通常需要使用瓣叶组织或心包。使用经光氧化处理的牛心包可能是一种替代方法，这种组织不易钙化。本研究的目的是评估经光氧化处理的牛心包组织在人类房室瓣重建中的应用。在2001年7月至2006年9月期间，21例患有复杂瓣膜病变的患者接受了经光氧化处理的心包重建手术。心包补片用于2例患者的三尖瓣瓣叶重建、6例患者的二尖瓣瓣叶重建、1例患者的三尖瓣环重建以及12例患者的二尖瓣环重建。随访时间为13.9至43.2个月。围手术期有5例死亡。4例患者出现重建失败，1例患者的心包补片变薄并穿孔，无感染或磨损迹象。其他患者未发生血栓栓塞、心内膜炎、出血并发症或重建失败的超声心动图表现。经光氧化处理的牛心包是用于房室瓣结构复杂重建的一种多功能材料。然而，其耐久性应在随机试验中与其他替代组织进行比较研究。
