Peer Jason, Bennett Melanie E, Bellack Alan S
Veterans Affairs Capitol Health Care Network Mental Illness, Research, Education, and Clinical Center, Baltimore, MD, USA.
J Nerv Ment Dis. 2009 Aug;197(8):631-4. doi: 10.1097/NMD.0b013e3181b08bf4.
Several investigations of cognitive functioning in individuals with schizophrenia and co-occurring cocaine use have yielded mixed results when compared with samples with schizophrenia only. However, no studies have specifically compared remitted and current cocaine dependence in schizophrenia. Such an analysis could help clarify the degree and type of cognitive impairment associated with cocaine dependence in schizophrenia. Two samples of individuals with schizophrenia - those with current cocaine dependence (n = 72) and those with cocaine dependence in remission (n = 48) were compared on a brief neuropsychological test battery. Parallel current dependent and remitted samples with affective disorder (n = 65 and n = 55) were also included in the analyses. Results yielded few neuropsychological differences between remitted and current dependent states across the SZ and AD groups. These findings suggest that cognitive impairment may be relatively static in these populations.
与仅患有精神分裂症的样本相比，几项针对同时患有精神分裂症和可卡因使用障碍的个体的认知功能调查结果不一。然而，尚无研究专门比较精神分裂症患者目前的可卡因依赖状态与已戒除可卡因依赖的状态。这样的分析有助于阐明与精神分裂症患者可卡因依赖相关的认知障碍的程度和类型。在一项简短的神经心理测试组中，对两组精神分裂症患者样本进行了比较，一组是目前患有可卡因依赖的患者（n = 72），另一组是已戒除可卡因依赖的患者（n = 48）。分析中还纳入了情感障碍的平行当前依赖组和已戒除组样本（n = 65和n = 55）。结果显示，在精神分裂症组和情感障碍组中，已戒除组和当前依赖组之间几乎没有神经心理学差异。这些发现表明，在这些人群中认知障碍可能相对稳定。
