Evans Keith, Law Simon K, Walt John, Buchholz Patricia, Hansen Jan
Global Health Outcomes, Wolters Kluwer Health, Chester, United Kingdom.
Clin Ophthalmol. 2009;3:433-45. doi: 10.2147/opth.s6024. Epub 2009 Aug 3.
It is well accepted that conditions that cause central vision loss (CVL) have a negative impact on functional ability and quality of life (QoL), but the impact of diseases that cause peripheral vision loss (PVL) is less well understood. Focusing on glaucoma and age-related macular degeneration (ARMD), the effects of CVL and PVL on QoL were compared.
A systematic literature review of publications reporting QoL in patients with CVL or PVL identified 87 publications using four generic (Short-Form Health Survey-36 and -12, EuroQoL EQ-5D and Sickness Impact Profile) and five vision-specific (National Eye Institute Visual Function Questionnaire-51, -39, and -25, Impact of Vision Impairment and Visual Function-14) QoL instruments; 33 and 15 publications reported QoL in ARMD and glaucoma, respectively.
QoL was impaired to a similar extent by diseases associated with PVL and CVL, but different domains were affected. In contrast to ARMD, mental aspects appeared to be affected more than physical aspects in patients with glaucoma.
The differential impact upon QoL might be a function of the pathology of the diseases, for example potential for blindness and better ability to perform physical tasks due to retention of central vision may explain these observations in glaucoma.
导致中心视力丧失（CVL）的疾病会对功能能力和生活质量（QoL）产生负面影响，这一点已得到广泛认可，但导致周边视力丧失（PVL）的疾病的影响则了解较少。以青光眼和年龄相关性黄斑变性（ARMD）为重点，比较了CVL和PVL对生活质量的影响。
对报告CVL或PVL患者生活质量的出版物进行系统的文献综述，使用四种通用（简短健康调查-36和-12、欧洲生活质量EQ-5D和疾病影响量表）和五种视力特定（美国国立眼科研究所视觉功能问卷-51、-39和-25、视力损害影响和视觉功能-14）生活质量工具确定了87篇出版物；分别有33篇和15篇出版物报告了ARMD和青光眼患者的生活质量。
与PVL和CVL相关的疾病对生活质量的损害程度相似，但受影响的领域不同。与ARMD不同，青光眼患者的心理方面似乎比身体方面受到的影响更大。
对生活质量的不同影响可能是疾病病理的一种作用，例如，失明的可能性以及由于中心视力保留而更好地执行身体任务的能力可能解释了青光眼的这些观察结果。
