Global Health Outcomes, Wolters Kluwer Pharma Solutions, Chester, UK.
Drugs Aging. 2009;26(11):933-50. doi: 10.2165/11316830-000000000-00000.
Chronic diseases have a long-term negative impact on quality of life (QOL). Decreased QOL is associated with increased financial burden on healthcare systems and society. However, few publications have investigated the impact of glaucoma on patients' QOL in comparison with other chronic diseases observed in patients with similar demographic characteristics. To this end, a systematic literature search to assess QOL in glaucoma and three other chronic diseases (osteoporosis, type 2 diabetes mellitus and dementia) was performed. A total of 146 publications were identified that reported QOL using six commonly used generic QOL instruments: 36-, 12- and 20-item Short-Form Health Surveys (SF-36, -12 and -20), EuroQoL (EQ-5D), Sickness Impact Profile (SIP) and the Health Utilities Index-Mark III (HUI-III). The publication breakdown was as follows: glaucoma (10%), osteoporosis (26%), diabetes (52%) and dementia (12%); one publication assessed QOL in glaucoma, diabetes and dementia. QOL was affected to a similar or slightly lesser degree by glaucoma than by osteoporosis, diabetes or dementia. Among the publications reporting SF-36, -12 and -20 evaluations, physical component scores were generally lower than mental component scores across all diseases. QOL was affected more in patients with glaucoma than in demographically matched non-glaucomatous controls according to SF-20 assessment. EQ-5D and SIP results showed that QOL decreased as the severity of glaucoma increased. Patients with glaucoma had the lowest scores on the SIP instrument, indicating better QOL than patients with osteoporosis or diabetes (no data were available on dementia). The HUI-III instrument identified poorer QOL in patients with dementia than other diseases, probably due to cognitive deficits. However, for some of the instruments, data were scarce, and interpretation of the results should be conservative. Although there are limited published QOL studies in glaucoma, its impact on QOL appears to be broadly similar to that of other serious chronic diseases. Development of a QOL instrument that measures vision-specific and general health aspects would better document the impact of glaucoma on QOL and would facilitate comparisons with other chronic disease states.
慢性病对生活质量（QOL）有长期的负面影响。生活质量下降与医疗保健系统和社会的经济负担增加有关。然而，与具有相似人口统计学特征的患者中观察到的其他慢性疾病相比，很少有出版物研究青光眼对患者生活质量的影响。为此，进行了一项系统的文献检索，以评估青光眼以及其他三种慢性疾病（骨质疏松症、2 型糖尿病和痴呆）的生活质量。共确定了 146 篇报告使用六种常用通用生活质量工具评估生活质量的出版物：36、12 和 20 项简短健康调查（SF-36、-12 和 -20）、欧洲五维健康量表（EQ-5D）、疾病影响量表（SIP）和健康效用指数-III （HUI-III）。出版物的细分情况如下：青光眼（10%）、骨质疏松症（26%）、糖尿病（52%）和痴呆（12%）；一篇出版物评估了青光眼、糖尿病和痴呆的生活质量。生活质量受青光眼的影响与骨质疏松症、糖尿病或痴呆相似或略小。在报告 SF-36、-12 和 -20 评估的出版物中，身体成分评分普遍低于所有疾病的心理成分评分。根据 SF-20 评估，青光眼患者的生活质量受影响程度大于人口统计学匹配的非青光眼对照患者。EQ-5D 和 SIP 结果表明，随着青光眼严重程度的增加，生活质量下降。青光眼患者在 SIP 量表上的得分最低，表明生活质量优于骨质疏松症或糖尿病患者（无痴呆数据）。HUI-III 量表确定痴呆患者的生活质量比其他疾病差，可能是由于认知缺陷。然而，对于一些工具，数据稀缺，结果的解释应该保守。尽管青光眼的生活质量研究有限，但它对生活质量的影响似乎与其他严重慢性疾病大致相似。开发一种衡量视力特定和一般健康方面的生活质量工具将更好地记录青光眼对生活质量的影响，并有助于与其他慢性疾病状态进行比较。
