Pierce Joshua G, Waller David L, Wipf Peter
Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, U.S.A.
J Organomet Chem. 2007 Oct 1;692(21):4618-4629. doi: 10.1016/j.jorganchem.2007.05.035.
Addition of in situ generated di- or trisubstituted alkenylalanes to N-acyliminium ions provides rapid access to functionalized isoindolinones. Subsequent ring closing metathesis leads to tricyclic products. These transformations proceed under mild conditions and allow for the convergent synthesis of biologically significant scaffolds from readily available starting materials.
将原位生成的二取代或三取代链烯基丙氨酸添加到N-酰基亚胺离子中，可快速获得官能化异吲哚啉酮。随后的闭环复分解反应生成三环产物。这些转化在温和条件下进行，并且能够从易得的起始原料进行汇聚合成具有生物学意义的骨架。
