Petronijevic Filip, Timmons Cody, Cuzzupe Anthony, Wipf Peter
Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania, 15260, USA.
Chem Commun (Camb). 2009 Jan 7(1):104-6. doi: 10.1039/b816989f. Epub 2008 Nov 11.
The key steps of a versatile new protocol for the convergent synthesis of 3,4-disubstituted indoles are the addition of an alpha-lithiated alkylaminofuran to a carbonyl compound, a microwave-accelerated intramolecular Diels-Alder cycloaddition and an in situ double aromatization reaction.
一种用于3,4-二取代吲哚汇聚合成的通用新方案的关键步骤是将α-锂化烷基氨基呋喃加成到羰基化合物上、微波加速的分子内狄尔斯-阿尔德环加成反应以及原位双芳构化反应。