一种用于合成4-取代吲哚的微波辅助分子内呋喃-狄尔斯-阿尔德方法。
A microwave assisted intramolecular-furan-Diels-Alder approach to 4-substituted indoles.
作者信息
Petronijevic Filip, Timmons Cody, Cuzzupe Anthony, Wipf Peter
机构信息
Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania, 15260, USA.
出版信息
Chem Commun (Camb). 2009 Jan 7(1):104-6. doi: 10.1039/b816989f. Epub 2008 Nov 11.
Abstract
The key steps of a versatile new protocol for the convergent synthesis of 3,4-disubstituted indoles are the addition of an alpha-lithiated alkylaminofuran to a carbonyl compound, a microwave-accelerated intramolecular Diels-Alder cycloaddition and an in situ double aromatization reaction.
摘要
一种用于3,4-二取代吲哚汇聚合成的通用新方案的关键步骤是将α-锂化烷基氨基呋喃加成到羰基化合物上、微波加速的分子内狄尔斯-阿尔德环加成反应以及原位双芳构化反应。
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