Department of Natural Sciences, Manchester Metropolitan University, Chester Street, Manchester, United Kingdom, M15GD.
J Org Chem. 2020 Apr 17;85(8):5615-5628. doi: 10.1021/acs.joc.0c00482. Epub 2020 Mar 31.
Herein we report our full investigation into the calcium catalyzed generation and trapping of -acyliminium ions from readily available 3-hydroxyisoindolinones. We have successfully employed a range of traditional nucleophiles including carbon, nitrogen, and sulfur containing reactive partners. The reaction is tolerant to a wide range of functionalities and provides high value scaffolds in good to excellent yields.
在此，我们报告了对钙催化生成和捕获 - 酰亚胺离子的全面研究，该离子来自易得的 3-羟基异吲哚啉酮。我们已经成功地使用了一系列传统的亲核试剂，包括含碳、氮和硫的反应性伙伴。该反应对广泛的官能团具有耐受性，并以良好至优秀的收率提供高价值的支架。
