人免疫缺陷病毒1包膜糖蛋白gp160依赖锚定序列的内源性加工以供CD4+ T细胞识别
Anchor sequence-dependent endogenous processing of human immunodeficiency virus 1 envelope glycoprotein gp160 for CD4+ T cell recognition.
作者信息
Polydefkis M, Koenig S, Flexner C, Obah E, Gebo K, Chakrabarti S, Earl P L, Moss B, Siliciano R F
机构信息
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
出版信息
J Exp Med. 1990 Mar 1;171(3):875-87. doi: 10.1084/jem.171.3.875.
Abstract
Human CD4+ T cell clones and cell lines were shown to lyse recombinant vaccinia virus-infected cells that synthesize the HIV-1 envelope glycoprotein gp160. The processing of endogenously synthesized gp160 for recognition by CD4+ T cells required that the protein, after synthesis on the rough endoplasmic reticulum and during subsequent cellular transport, remain attached to the luminal/extracellular membrane face by a hydrophobic anchor sequence.
摘要
已证明人类CD4+ T细胞克隆和细胞系可裂解重组痘苗病毒感染的、合成HIV-1包膜糖蛋白gp160的细胞。内源性合成的gp160要被CD4+ T细胞识别，其加工过程要求该蛋白在粗面内质网上合成后以及随后的细胞转运过程中，通过疏水锚定序列保持附着于管腔/细胞外膜表面。
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