耐盐真菌 Penicillium chrysogenum 发酵液中的脑苷脂和 2-吡啶酮生物碱。
Cerebrosides and 2-pyridone alkaloids from the halotolerant fungus Penicillium chrysogenum grown in a hypersaline medium.
机构信息
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China.
出版信息
J Nat Prod. 2011 May 27;74(5):1298-302. doi: 10.1021/np1008976. Epub 2011 Mar 7.
Five new cerebrosides, chrysogesides A-E (1-5), and two new 2-pyridone alkaloids, chrysogedones A and B (6 and 7), were isolated from the fermentation broth of Penicillium chrysogenum PXP-55, a halotolerant fungus grown in a hypersaline medium. Among them, chrysogesides B-D (2-4) are the first cerebrosides that contain an unsaturated C(19)-fatty acid. Their structures were identified by spectroscopic and chemical methods, including CD spectroscopy as well as the modified Mosher's method. Compound 2 showed antimicrobial activity against Enterobacter aerogenes with an MIC value of 1.72 μM.
从在高盐培养基中生长的耐盐真菌 Penicillium chrysogenum PXP-55 的发酵液中分离得到了 5 种新的脑苷脂，即 chrysogesides A-E（1-5），和 2 种新的 2-吡啶酮生物碱，chrysogedones A 和 B（6 和 7）。其中，chrysogesides B-D（2-4）是首次发现含有不饱和 C(19)-脂肪酸的脑苷脂。通过光谱和化学方法，包括圆二色光谱和改良的 Mosher 法，确定了它们的结构。化合物 2 对 Enterobacter aerogenes 具有抗菌活性，MIC 值为 1.72 μM。
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