Navalakhe Rajshri M, Nandedkar Tarala D
National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai, 400012, India.
Indian J Exp Biol. 2007 Feb;45(2):160-5.
Nanotechnology is the development of engineered devices at the atomic, molecular and macromolecular level in nanometer range. Nanoparticles have potential application in medical field including diagnostics and therapeutics. Nanotechnology devices are being developed for diagnosis of cancer and infectious diseases which can help in early detection of the disease. Advances in nanotechnology also proved beneficial in therapeutic field such as drug discovery, drug delivery and gene/protein delivery. Nanoparticles can be constructed by various methodology so that effect can be targeted at desired site. In this review, some of the applications of nanoparticles in medicine as diagnostics and therapeutics which can be employed safely at the clinical level have been described. On other hand, as the particles become generally smaller their likehood of causing harm to the lung increases. Therefore, there is a need to study safety of nanoparticles.
纳米技术是在纳米范围内的原子、分子和大分子水平上开发工程设备。纳米颗粒在包括诊断和治疗在内的医学领域具有潜在应用。正在开发用于癌症和传染病诊断的纳米技术设备，这有助于疾病的早期检测。纳米技术的进展在治疗领域也被证明是有益的，如药物发现、药物递送和基因/蛋白质递送。纳米颗粒可以通过各种方法构建，以便将效果靶向到期望的部位。在这篇综述中，描述了纳米颗粒在医学中作为诊断和治疗手段的一些应用，这些应用可以在临床水平上安全使用。另一方面，随着颗粒通常变得更小，它们对肺部造成伤害的可能性增加。因此，有必要研究纳米颗粒的安全性。
