Kim Eunjung, Yang Jaemoon, Choi Jihye, Suh Jin-Suck, Huh Yong-Min, Haam Seungjoo
Department of Chemical and Biomolecular Engineering, College of Engineering, Yonsei University, Seoul 120-749, Republic of Korea.
Nanotechnology. 2009 Sep 9;20(36):365602. doi: 10.1088/0957-4484/20/36/365602. Epub 2009 Aug 18.
For the synthesis of biocompatible photothermal agents, gold nanorod-embedded polymeric nanoparticles (GPNs) were synthesized using a nanoprecipitation method. Uniform gold nanorods (GNRs), which are sensitive to a photothermal effect by near-infrared (NIR) light, with an aspect ratio of 4.0 were synthesized by a seed-mediated growth method. The hydroxyl groups of polycaprolactone diol (PCL diOH) were modified by esterification with mercaptopropionic acid to give a dithiol (polycaprolactone dithiol, PCL diSH) as a phase transfer and capping agent. Subsequently, hexadecyltrimethylammonium bromide (CTAB), a stabilizer of GNRs, was exchanged and/or removed by PCL diSH. PCL diSH-coated GNRs were further wrapped in a hydrophilic polymer, Pluronic F127, as a stabilizer. These newly formulated GPNs exhibit excellent stability in water and a maximum absorbance in the NIR region indicating a highly efficient surface plasmon resonance effect, phenomena useful for photothermal agents.
为了合成生物相容性光热剂，采用纳米沉淀法合成了嵌入金纳米棒的聚合物纳米颗粒（GPNs）。通过种子介导生长法合成了长径比为4.0、对近红外（NIR）光的光热效应敏感的均匀金纳米棒（GNRs）。聚己内酯二醇（PCL diOH）的羟基通过与巯基丙酸酯化进行修饰，得到二硫醇（聚己内酯二硫醇，PCL diSH）作为相转移和封端剂。随后，GNRs的稳定剂十六烷基三甲基溴化铵（CTAB）被PCL diSH交换和/或去除。用亲水性聚合物Pluronic F127作为稳定剂进一步包裹PCL diSH包覆的GNRs。这些新配制的GPNs在水中表现出优异的稳定性，并且在近红外区域具有最大吸光度，表明具有高效的表面等离子体共振效应，这对于光热剂来说是很有用的现象。
