Oxorn D, Knox J W, Hill J
Department of Anaesthesia, Halifax Infirmary Hospital, Nova Scotia.
Can J Anaesth. 1990 Mar;37(2):206-9. doi: 10.1007/BF03005471.
The effectiveness of esmolol, an ultra short-acting cardioselective beta blocker, in the prevention and treatment of post-intubation haemodynamic perturbations, was investigated. Forty-eight ASA physical status I and II patients undergoing hysterectomy were randomly assigned to receive a single intravenous bolus of placebo, esmolol 100 mg, or esmolol 200 mg in a double-blind fashion. This was administered over 15 sec, and immediately followed by thiopentone 3-5 mg.kg-1, succinylcholine 1.5 mg.kg-1, and tracheal intubation 90 sec later. The heart rate following induction of anaesthesia was lower in the esmolol 200 mg group (P less than 0.01); following intubation, the increase in heart rate in the placebo group was greater than in the esmolol groups (P less than 0.05). The systolic blood pressure post-induction was lower in the esmolol 200 mg group (P less than 0.05); following intubation, however, no significant differences were seen among groups in systolic, diastolic, or mean blood pressures. Following tracheal intubation, the incidence of ventricular arrhythmias was lower in the esmolol groups (P less than 0.05). In summary, esmolol in 100 mg and 200 mg doses was effective in mitigating the haemodynamic response following tracheal intubation.
研究了超短效心脏选择性β受体阻滞剂艾司洛尔在预防和治疗插管后血流动力学紊乱方面的有效性。48例接受子宫切除术的美国麻醉医师协会（ASA）身体状况I级和II级患者被随机分配，以双盲方式接受单次静脉推注安慰剂、100mg艾司洛尔或200mg艾司洛尔。药物在15秒内推注完毕，随后立即给予3 - 5mg·kg⁻¹硫喷妥钠、1.5mg·kg⁻¹琥珀酰胆碱，并在90秒后进行气管插管。艾司洛尔200mg组麻醉诱导后的心率较低（P < 0.01）；插管后，安慰剂组心率的增加大于艾司洛尔组（P < 0.05）。艾司洛尔200mg组诱导后的收缩压较低（P < 0.05）；然而，插管后，各组的收缩压、舒张压或平均血压之间未见显著差异。气管插管后，艾司洛尔组室性心律失常的发生率较低（P < 0.05）。总之，100mg和200mg剂量的艾司洛尔在减轻气管插管后的血流动力学反应方面是有效的。
