Heiskala Juha, Pollari Mika, Metsäranta Marjo, Grant P Ellen, Nissilä Ilkka
BioMag Laboratory, HUSLAB, Helsinki University Central Hospital, PO Box 340, FI-00029 HUS, Finland.
Opt Express. 2009 Aug 17;17(17):14977-92. doi: 10.1364/oe.17.014977.
Diffuse optical imaging is an emerging medical imaging modality based on near-infrared and visible red light. The method can be used for imaging activations in the human brain. In this study, a deformable probabilistic atlas of the distribution of tissue types within the term neonatal head was created based on MR images. The use of anatomical prior information provided by such atlas in reconstructing brain activations from optical imaging measurements was studied using Monte Carlo simulations. The results suggest that use of generic anatomical information can greatly improve the spatial accuracy and robustness of the reconstruction when noise is present in the data.
扩散光学成像是一种基于近红外和可见红光的新兴医学成像方式。该方法可用于对人类大脑中的激活情况进行成像。在本研究中，基于磁共振图像创建了足月新生儿头部组织类型分布的可变形概率图谱。利用蒙特卡罗模拟研究了在从光学成像测量中重建大脑激活情况时使用此类图谱提供的解剖学先验信息的情况。结果表明，当数据中存在噪声时，使用通用解剖学信息可大大提高重建的空间准确性和稳健性。
