Gilmour Susan M
Division of Pediatric Gastroenterology/Nutrition, Stollery Children's Hospital, University of Alberta, Edmonton, Alberta.
Paediatr Child Health. 2004 Dec;9(10):700-704. doi: 10.1093/pch/9.10.700.
Neonatal jaundice persisting beyond 14 days of age is a common clinical scenario. The vast majority of affected children have a benign unconjugated hyperbilirubinemia, but included in this clinical presentation is a group of neonates with conjugated hyperbilirubinemia and liver disease. Early identification of liver disease improves the infant's outcome, especially for those with extrahepatic biliary atresia. The present paper reviews the approach to the neonate with prolonged jaundice, including clinical presentation, when to proceed with initial investigations, timing of referral, further investigations and management, and provides an overview of the more common causes of neonatal cholestatic liver disease.
新生儿黄疸持续超过14日龄是一种常见的临床情况。绝大多数受影响的儿童患有良性非结合性高胆红素血症，但在这一临床表现中，包括一组患有结合性高胆红素血症和肝病的新生儿。早期识别肝病可改善婴儿的预后，尤其是对于那些患有肝外胆道闭锁的婴儿。本文综述了对黄疸持续时间延长的新生儿的处理方法，包括临床表现、何时进行初步检查、转诊时机、进一步检查和处理，并概述了新生儿胆汁淤积性肝病较常见的病因。
