草药对孕烷X受体（PXR）和组成型雄烷受体（CAR）的激活作用。
Activation of pregnane X receptor (PXR) and constitutive androstane receptor (CAR) by herbal medicines.
作者信息
Chang Thomas K H
机构信息
Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, BC, Canada.
出版信息
AAPS J. 2009 Sep;11(3):590-601. doi: 10.1208/s12248-009-9135-y. Epub 2009 Aug 18.
Abstract
Pregnane X receptor (PXR) and constitutive androstane receptor (CAR) are transcription factors that control the expression of a broad array of genes involved not only in transcellular transport and biotransformation of many drugs, other xenochemicals, and endogenous substances, such as bile acid, bilirubin, and certain vitamins, but also in various physiological/pathophysiological processes such as lipid metabolism, glucose homeostasis, and inflammation. Ligands of PXR and CAR are chemicals of diverse structures, including naturally occurring compounds present in herbal medicines. The overall aim of this article is to provide an overview of our current understanding of the role of herbal medicines as modulators of PXR and CAR.
摘要
孕烷X受体（PXR）和组成型雄甾烷受体（CAR）是转录因子，它们不仅控制许多药物、其他外源性化学物质和内源性物质（如胆汁酸、胆红素和某些维生素）的跨细胞转运和生物转化相关的大量基因的表达，还控制脂质代谢、葡萄糖稳态和炎症等各种生理/病理生理过程。PXR和CAR的配体是结构多样的化学物质，包括草药中存在的天然化合物。本文的总体目的是概述我们目前对草药作为PXR和CAR调节剂作用的理解。
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