Rodrigues Renata S, Izidoro Luiz Fernando M, de Oliveira Robson J, Sampaio Suely V, Soares Andreimar M, Rodrigues Veridiana M
Instituto de Genética e Bioquímica, Universidade Federal de Uberlândia-Uberlândia-MG, Brazil.
Protein Pept Lett. 2009;16(8):894-8. doi: 10.2174/092986609788923266.
Phospholipases A(2) (PLA(2)) are enzymes of high medical scientific interest due to their involvement in a large number of human inflammatory diseases. PLA(2) constitute a diverse family of enzymes which catalyses the hydrolysis of the sn-2 ester bond in glycerophospholipids and exhibit a wide range of physiological and pathological effects. The ubiquitous nature of PLA(2) highlights the important role they play in many biological processes, as cell signaling and cell growth, including the generation of proinflammatory lipid mediators such as prostaglandin and leukotrienes, regulation of lipid mediators. The activity and expression of several PLA(2) isoforms are increased in several human cancers, suggesting that these enzymes have a central role in both tumor development and progression and can be targets for anti-cancer drugs. On the other hand, some PLA(2) isolated from Viperidae venoms are capable to induce antitumoral activity. In summary PLA(2) from snake venoms can be a new class of anticancer agents and provide new molecular and biological insights of cancer development.
磷脂酶A(2)（PLA(2)）因其参与大量人类炎症性疾病而成为具有高度医学科学研究价值的酶。PLA(2)构成了一个多样化的酶家族，它们催化甘油磷脂中sn-2酯键的水解，并表现出广泛的生理和病理效应。PLA(2)的普遍存在突出了它们在许多生物过程中所起的重要作用，如细胞信号传导和细胞生长，包括促炎脂质介质如前列腺素和白三烯的产生、脂质介质的调节。几种PLA(2)同工型的活性和表达在几种人类癌症中增加，这表明这些酶在肿瘤发生和发展中起着核心作用，并且可以成为抗癌药物的靶点。另一方面，从蝰蛇科毒液中分离出的一些PLA(2)能够诱导抗肿瘤活性。总之，蛇毒中的PLA(2)可以成为一类新型抗癌药物，并为癌症发展提供新的分子和生物学见解。
