Khazzani Hamza, Allali Fadoua, Bennani Loubna, Ichchou Linda, El Mansouri Laila, Abourazzak Fatima E, Abouqal Redouane, Hajjaj-Hassouni Najia
Department of Rheumatology, El Ayachi hospital, University Hospital of Rabat-Sale, Sale, Morocco.
BMC Public Health. 2009 Aug 18;9:297. doi: 10.1186/1471-2458-9-297.
Several factors, in addition to low bone mineral density (BMD), have been identified as risks for fractures, including reduced levels of physical activity, poor balance and low physical performance. The aim of this study was to evaluate the relationship between physical performance measures, BMD, falls, and the risk of peripheral fracture in a population sample of Moroccan women.
484 healthy women were included. Three measures were used to assess physical performance: timed get-up-and-go test 'TGUGT', five-times-sit-to-stand test '5 TSTS' and 8-feet timed walk '8 FTW'. The association between physical performance measures and BMD, peripheral fracture and falls was performed by univariate and multivariate analysis.
The mean age was 55.1 years. Higher 'TGUGT', '5 TSTS', '8 FTW' test scores were associated with lower BMD measured at different sites (p range from < 0.001 to 0.005). The relationship between the three tests and BMD in all measured sites remained significant after multiple linear regression (p range from <0.001 to 0.026). In the group of post-menopausal patients, the scores of 'TGUGT' and '8 FTW' were significantly higher in fractured patients compared with patients without. After logistic regression, a score of 'TGUGT' > 14.2 sec, a score of '5 TSTS' > 12.9 sec and a score of '8 FTW' > 4.6 sec respectively, increased the probability of anterior peripheral fracture by 2.7, 2.2 and 2.3 (OR = 2.7; 95% CI = 1.2-6.4, OR = 2.2; 95% CI = 1.1-5.2; and OR = 2.3; 95% CI = 1.1-5.1). There was a significant positive correlation between the number of fall/year and the 3 tests. This correlation persisted after poisson regression.
This study suggested that low physical performance is associated with low BMD, and a high risk of history of falls and fractures.
除了低骨密度（BMD）外，还有几个因素被确定为骨折风险因素，包括身体活动水平降低、平衡能力差和身体机能低下。本研究的目的是评估摩洛哥女性人群样本中身体机能指标、骨密度、跌倒与外周骨折风险之间的关系。
纳入484名健康女性。采用三项指标评估身体机能：计时起立行走测试（TGUGT）、五次坐立测试（5TSTS）和8英尺计时步行（8FTW）。通过单因素和多因素分析研究身体机能指标与骨密度、外周骨折和跌倒之间的关联。
平均年龄为55.1岁。较高的TGUGT、5TSTS、8FTW测试分数与不同部位较低的骨密度相关（p值范围为<0.001至0.005）。多元线性回归后，三项测试与所有测量部位骨密度之间的关系仍然显著（p值范围为<0.001至0.026）。在绝经后患者组中，骨折患者的TGUGT和8FTW分数显著高于未骨折患者。逻辑回归后，TGUGT分数>14.2秒、5TSTS分数>12.9秒和8FTW分数>4.6秒分别使外周前侧骨折的概率增加2.7、2.2和2.3倍（OR=2.7；95%CI=1.2-6.4，OR=2.2；95%CI=1.1-5.2；OR=2.3；95%CI=1.1-5.1）。每年跌倒次数与这三项测试之间存在显著正相关。泊松回归后这种相关性仍然存在。
本研究表明，身体机能低下与低骨密度、跌倒史和骨折高风险相关。
