α-酮戊二酸与术后肌肉分解代谢
Alpha-ketoglutarate and postoperative muscle catabolism.
作者信息
Wernerman J, Hammarqvist F, Vinnars E
机构信息
Department of Anaesthesiology and Intensive Care, St Göran's Hospital, Karolinska Institute, Stockholm, Sweden.
出版信息
Lancet. 1990 Mar 24;335(8691):701-3. doi: 10.1016/0140-6736(90)90811-i.
PMID:1969067
Abstract
The hypothesis that muscle protein catabolism after trauma is associated with a shortage of alpha-ketoglutarate, rather than glutamine, was tested. Addition of alpha-ketoglutarate to postoperative total parenteral nutrition prevented the decrease in muscle protein synthesis and free glutamine that usually occurs after surgery. alpha-ketoglutarate supplementation may improve recovery after trauma.
摘要
研究了创伤后肌肉蛋白分解代谢与α-酮戊二酸缺乏而非谷氨酰胺缺乏相关的假说。在术后全肠外营养中添加α-酮戊二酸可防止通常在手术后出现的肌肉蛋白合成和游离谷氨酰胺的减少。补充α-酮戊二酸可能会改善创伤后的恢复情况。
Zotero 插件