Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Evanston, Illinois 60208, USA.
J Interferon Cytokine Res. 2009 Sep;29(9):531-7. doi: 10.1089/jir.2009.0070.
RNA viruses in the paramyxovirus family have evolved a number of strategies to escape host cell surveillance and antiviral responses. One mechanism exploited by a number of viruses in this family is direct targeting of cytokine-inducible transcription regulators in the STAT family. Diverse members of this large virus family effectively suppress STAT signaling by the actions of their V proteins, or the related proteins derived from alternate viral mRNAs. These viral proteins have distinct means of targeting STATs, resulting in a variety of negative effects on STATs and their signal transduction. Recent developments in understanding STAT targeting will be reviewed.
副黏病毒科的 RNA 病毒已经进化出许多策略来逃避宿主细胞的监视和抗病毒反应。该科的许多病毒利用的一种机制是直接靶向细胞因子诱导的转录调节因子家族中的 STAT。该大病毒家族的不同成员通过其 V 蛋白或源自替代病毒 mRNA 的相关蛋白有效地抑制 STAT 信号。这些病毒蛋白具有不同的靶向 STAT 的方式，导致对 STAT 及其信号转导的多种负面影响。将对 STAT 靶向作用的最新研究进展进行综述。
