Mantovani Alberto, Garlanda Cecilia, Locati Massimo
Istituto Clinico Humanitas IRCCS, via Manzoni 56, 20089 Rozzano, Italy.
Arterioscler Thromb Vasc Biol. 2009 Oct;29(10):1419-23. doi: 10.1161/ATVBAHA.108.180497. Epub 2009 Aug 20.
Diversity and plasticity are hallmarks of mononuclear phagocytes, which are reflected in plaque formation and evolution. Different monocyte subsets, which differentially contribute to plaque infiltration and to atherosclerosis complications, have been identified. Similarly, depending on different environmental signals plaque-associated macrophages can express polarized pro- and antiatherogenic programs by influencing lipid metabolism, inflammatory responses, and plaque stability. Thus, a "macrophage balance" plays a major role in the pathogenesis of atherosclerotic plaques and affects evolution and complications of atherosclerosis.
多样性和可塑性是单核吞噬细胞的标志，这在斑块形成和演变中得以体现。已识别出不同的单核细胞亚群，它们对斑块浸润和动脉粥样硬化并发症的贡献各不相同。同样，根据不同的环境信号，斑块相关巨噬细胞可通过影响脂质代谢、炎症反应和斑块稳定性来表达极化的促动脉粥样硬化和抗动脉粥样硬化程序。因此，“巨噬细胞平衡”在动脉粥样硬化斑块的发病机制中起主要作用，并影响动脉粥样硬化的演变和并发症。
