Division of Renal Diseases and Hypertension, University of Colorado, Denver, Colo., USA.
Am J Nephrol. 2009;30(5):399-404. doi: 10.1159/000235731. Epub 2009 Aug 21.
Both ACE inhibitors and allopurinol have been shown to partially prevent metabolic syndrome induced by fructose. We tested the hypothesis that combined therapy might be more effective at blocking the metabolic syndrome induced with fructose.
Male Sprague-Dawley rats were fed a high fructose diet with or without allopurinol, captopril, or the combination for 20 weeks. A control group received a normal diet. All groups were pair-fed to assure equivalent caloric intake.
Despite reduced energy intake, the fructose-fed rats developed features of metabolic syndrome including elevated blood pressure, abdominal obesity, hypertriglyceridemia, hyperuricemia and hyperinsulinemia. While both allopurinol and captopril alone tended to reduce features of the metabolic syndrome, the combined therapy was synergistic, with significant reduction in blood pressure, less accumulation of abdominal fat, an improvement in the dyslipidemia and a complete prevention of insulin resistance.
A high fructose diet can induce metabolic syndrome even in the setting of caloric restriction. Captopril and allopurinol synergistically reduce features of the metabolic syndrome, especially hypertension, insulin resistance and dyslipidemia. Combination allopurinol and ACE inhibitor therapy might provide a superior means to prevent diabetes and cardiovascular disease.
血管紧张素转换酶抑制剂和别嘌呤醇都已被证明可以部分预防果糖引起的代谢综合征。我们检验了这样一种假设，即联合治疗可能更有效地阻止果糖引起的代谢综合征。
雄性 Sprague-Dawley 大鼠用高果糖饮食喂养，同时给予别嘌呤醇、卡托普利或两者联合治疗 20 周。对照组给予正常饮食。所有组均进行配对喂养，以确保摄入等量的热量。
尽管能量摄入减少，果糖喂养的大鼠仍出现代谢综合征的特征，包括血压升高、腹部肥胖、高三酰甘油血症、高尿酸血症和高胰岛素血症。虽然别嘌呤醇和卡托普利单独治疗都倾向于减轻代谢综合征的特征，但联合治疗具有协同作用，可显著降低血压、减少腹部脂肪堆积、改善血脂异常并完全预防胰岛素抵抗。
即使在热量限制的情况下，高果糖饮食也可诱导代谢综合征。卡托普利和别嘌呤醇协同减轻代谢综合征的特征，特别是高血压、胰岛素抵抗和血脂异常。联合应用别嘌呤醇和 ACE 抑制剂治疗可能是预防糖尿病和心血管疾病的更好方法。
