Zhang Su-Hua, Chang Jing-Jing, Li Li
Department of Forensic Medicine, Medical College of Soochow University, Suzhou 215123, China.
Fa Yi Xue Za Zhi. 2009 Jun;25(3):187-91.
To evaluate the application value of Mentype Argus X-8 kit in Chinese population, and to gather the genetic data of the eight X-STR loci.
The X-STR of 177 blood samples of unrelated East China Han population and 104 duo paternity testing cases was typed using Mentype Argus X-8 kit. The allele frequency and genetic data of the eight loci were investigated.
The PIC of the eight X-STR loci was between 0.4454 and 0.9187. Among them, DXS10135 and DXS10101 had the highest PIC and exclusion rate in paternity cases. The other seven loci showed no difference in sex-related allele frequency except DXS7132. In addition, there were several new alleles detected including DXS10074 (allele 15.3), DXS10101 (allele 36) and DXS10134 (allele 37.3).
Eight X-STR loci included in Mentype Argus X-8 kit are high polymorphic and valuable.
评估Mentype Argus X-8试剂盒在中国人群中的应用价值，并收集8个X-STR基因座的遗传数据。
采用Mentype Argus X-8试剂盒对177例华东地区汉族无关个体血样及104例三联体亲子鉴定案例进行X-STR分型，分析8个基因座的等位基因频率及遗传数据。
8个X-STR基因座的PIC值在0.4454至0.9187之间。其中，DXS10135和DXS10101在亲子鉴定中的PIC值和排除率最高。除DXS7132外，其他7个基因座在性别相关等位基因频率上无差异。此外，还检测到多个新等位基因，包括DXS10074（等位基因15.3）、DXS10101（等位基因36）和DXS10134（等位基因37.3）。
Mentype Argus X-8试剂盒所包含的8个X-STR基因座具有高度多态性且具有应用价值。
