Fulop Andras M, Dhimmer Seema, Deluca James R, Johanson David D, Lenz Richard V, Patel Keyuri B, Douris Peter C, Enwemeka Chukuka S
Department of Physical Therapy, School of Health Professions, New York Institute of Technology, Old Westbury, New York, USA.
Photomed Laser Surg. 2009 Oct;27(5):695-702. doi: 10.1089/pho.2009.2550.
The effect of phototherapy on tissue repair was determined by aggregating the literature and using statistical meta-analysis to analyze pertinent studies published between 2000 and 2007.
Phototherapy has been used for more than 40 y; however, its efficacy on tissue repair remains contentious.
Related original studies were gathered from every available source. The papers were then screened and coded; those meeting pre-established inclusion criterion were subjected to meta-analysis, using Cohen's d statistic to determine treatment effect size.
Seventy effect sizes were computed from the 23 papers that met the inclusion criteria. The overall mean effect obtained was highly significant, d = +1.94 (95% confidence interval = 0.58-2.50). Further analyses revealed a similarly positive effect of phototherapy on tissue repair in experimental animal studies, d = +2.60, and a small to moderately positive effect in human cases of tissue repair, d = +0.34. The fail-safe number associated with the overall effect was 869; i.e., the number of additional studies in which phototherapy has negative or no effect on wound healing needed to negate the overall large effect size of + 1.94. The corresponding fail-safe numbers for experimental animal and human tissue repair studies were 612 and 64, respectively.
These findings indicate that phototherapy is a highly effective form of treatment for tissue repair, with stronger supporting evidence resulting from experimental animal studies than human studies.
通过汇总文献并运用统计元分析来分析2000年至2007年间发表的相关研究，以确定光疗对组织修复的影响。
光疗已应用40多年；然而，其对组织修复的疗效仍存在争议。
从所有可获取的来源收集相关原始研究。然后对论文进行筛选和编码；对符合预先设定纳入标准的论文进行元分析，使用科恩d统计量来确定治疗效果大小。
从符合纳入标准的23篇论文中计算出70个效果大小。获得的总体平均效果非常显著，d = +1.94（95%置信区间 = 0.58 - 2.50）。进一步分析显示，光疗在实验动物研究中对组织修复有类似的积极效果，d = +2.60，在人类组织修复病例中有小到中度的积极效果，d = +0.34。与总体效果相关的失效安全数为869；即需要有多少额外的研究表明光疗对伤口愈合有负面或无影响，才能抵消总体 +1.94 的大效果大小。实验动物和人类组织修复研究的相应失效安全数分别为612和64。
这些发现表明光疗是一种对组织修复非常有效的治疗形式，实验动物研究比人类研究提供了更强有力的支持证据。
