Perkhofer Susanne, Kainzner Barbara, Kehrel Beate E, Dierich Manfred P, Nussbaumer Walter, Lass-Flörl Cornelia
Department of Hygiene, Microbiology and Social Medicine, Division of Hygiene and Medical Microbiology, Innsbruck Medical University, Innsbruck, Austria.
J Infect Dis. 2009 Oct 1;200(7):1176-9. doi: 10.1086/605607.
Zygomycosis is increasingly recognized in immunocompromised hosts. We investigated whether platelets become activated after contact with Zygomycetes and adhere to conidial and hyphal structures using immunofluorescence. The platelets' influence on fungal viability was evaluated by assessing hyphal elongation and hyphal damage. Platelets became activated and strongly adhered to conidia and hyphae of Zygomycetes. Platelets induced time dependent damage to hyphae and significantly reduced (P<.05) hyphal elongation. We found that platelets possess antifungal capacities against Zygomycetes based on granule dependent mechanisms and significantly reduce fungal growth and spread, both of which are of major importance in evolving invasive disease.
接合菌病在免疫功能低下的宿主中越来越受到关注。我们通过免疫荧光研究了血小板与接合菌接触后是否会被激活，并黏附于分生孢子和菌丝结构上。通过评估菌丝伸长和菌丝损伤来评价血小板对真菌活力的影响。血小板被激活并强烈黏附于接合菌的分生孢子和菌丝上。血小板可诱导菌丝随时间出现损伤，并显著降低（P<0.05）菌丝伸长。我们发现，血小板基于颗粒依赖性机制具有抗接合菌的能力，并能显著减少真菌的生长和扩散，而这两者在侵袭性疾病的发展过程中都至关重要。
