Toxicon. 2010 Jan;55(1):166-70. doi: 10.1016/j.toxicon.2009.08.006. Epub 2009 Aug 20.
The study of snake venom-induced local tissue pathology has been predominantly based on experimental designs and concepts that view tissue alterations from a dichotomous, homogeneous and reductionist perspective. Experimental observations, however, indicate that cells and extracellular matrix are affected by venoms and toxins in a complex and heterogeneous fashion, and that the effect of whole venoms in whole organisms cannot be properly assessed by studying only the action of isolated toxins in isolated systems. It is proposed that a novel conceptual and methodological frame is necessary to better understand the complexity of these pathological alterations from a holistic, systems biology perspective.
蛇毒引起的局部组织病理学研究主要基于实验设计和概念，这些设计和概念从二分法、均匀和还原论的角度来看待组织变化。然而，实验观察表明，细胞和细胞外基质受到毒液和毒素的影响是复杂和不均匀的，而且通过仅研究分离的毒素在分离的系统中的作用，不能正确评估整个毒液在整个生物体中的作用。有人提出，需要一个新的概念和方法框架，从整体、系统生物学的角度更好地理解这些病理变化的复杂性。
