Edden Yair, Shih Shirley S, Wexner Steven D
Department of Colorectal Surgery, Cleveland Clinic, 2950 Cleveland Clinic Boulevard, Weston, FL 33331, USA.
Gastroenterol Clin North Am. 2009 Sep;38(3):541-5. doi: 10.1016/j.gtc.2009.06.010.
Colonic ulcerations can affect the entire colon and rectum, and have variable clinical presentation according to the anatomic location and underlying pathology. Diverse causes may lead to colonic ulceration, such as inflammatory bowel diseases, oral drugs (mostly nonsteroidal anti-inflammatory drugs), local or diffuse ischemia, and different intestinal microorganisms. An ulcer may also herald a concealed malignant disease. In most cases, colonic ulcerate is associated with diffuse colitis in the acute setup or with inflammatory bowel diseases, and to the lesser extent the ulceration is defined as solitary. This article focuses on two of the less commonly diagnosed diseases: solitary rectal ulcer syndrome and stercoral ulceration, both related to local tissue ischemia and often seen in the elderly population.
结肠溃疡可累及整个结肠和直肠,并根据解剖位置和潜在病理改变而有不同的临床表现。多种病因可导致结肠溃疡,如炎症性肠病、口服药物(主要是非甾体类抗炎药)、局部或弥漫性缺血以及不同的肠道微生物。溃疡也可能预示着隐匿性恶性疾病。在大多数情况下,结肠溃疡在急性期与弥漫性结肠炎或炎症性肠病相关,在较小程度上溃疡被定义为孤立性的。本文重点关注两种较少见的疾病:孤立性直肠溃疡综合征和粪性溃疡,两者均与局部组织缺血有关,且常见于老年人群。