Ford M J, Anderson J R, Gilmour H M, Holt S, Sircus W, Heading R C
Gastroenterology. 1983 Jun;84(6):1533-40.
A review of 40 patients with "solitary ulcer" of the rectum confirmed by rectal biopsy has provided information about the natural history of this unusual condition. At presentation, symptoms usually were the passage of blood and mucus per rectum, alteration in bowel habits, and anorectal pain. Solitary or multiple ulcers were found within 13 cm of the anal margin in 27 patients and were usually sited anteriorly; in 13 patients macroscopic ulceration was absent, though the histopathology of the rectal biopsy specimens was otherwise similar. Rectal mucosal prolapse was found in 25 of 29 patients examined specifically for this. Thirty-one patients were followed-up for a mean period of 4.8 yr (range 1-15 yr). In 22 patients, rectal ulceration was observed at presentation. In 14 of these patients, ulceration persisted despite treatment. In 9 patients presenting without macroscopic ulceration, rectal ulcers were not observed during follow-up; thus two patient groups were apparent. Neither medical nor local surgical treatment consistently achieved relief of symptoms or healing of the lesion.
一项对40例经直肠活检确诊为直肠“孤立性溃疡”患者的回顾性研究，提供了关于这种罕见病症自然史的信息。就诊时，症状通常为经直肠便血和黏液、排便习惯改变以及肛门直肠疼痛。27例患者在距肛缘13厘米范围内发现有单个或多个溃疡，且通常位于前方；13例患者虽直肠活检标本的组织病理学表现相似，但未见肉眼可见的溃疡。在专门检查直肠黏膜脱垂的29例患者中，有25例发现有脱垂。31例患者接受了平均4.8年（范围1 - 15年）的随访。22例患者就诊时发现有直肠溃疡。其中14例患者尽管接受了治疗，溃疡仍持续存在。9例就诊时无肉眼可见溃疡的患者，随访期间未观察到直肠溃疡；因此明显分为两组患者。药物治疗和局部手术治疗均未能持续缓解症状或治愈病变。
