University Hospital for Infectious Diseases 'Dr Fran Mihaljevic', Mirogojska c. 8, 10000 Zagreb, Croatia.
Trans R Soc Trop Med Hyg. 2010 Mar;104(3):202-6. doi: 10.1016/j.trstmh.2009.05.018. Epub 2009 Aug 21.
This study presents the current status of human leptospirosis in Croatia from an epidemiological and clinical viewpoint. Data from annual reports of the Croatian Institute for Public Health as well as archives of the University Hospital for Infectious Diseases 'Dr Fran Mihaljevic' (UHID) in Zagreb were used in this retrospective cohort analysis. The mean yearly incidence of leptospirosis from 1990 to 2007 was 1.83/100 000 inhabitants, with an incidence >2.5/100 000 inhabitants recorded approximately every 3-4 years, making Croatia one of the countries with the highest incidence of human leptospirosis in Europe. In addition to the majority of sporadic cases, two minor outbreaks were recorded. The clinical burden and more detailed epidemiology of 130 patients hospitalised at UHID in the period 1997-2007 were also studied. Clinical presentations were as expected, with an overall case fatality rate (CFR) of 0.77%. The most commonly established infective serovars were Australis followed by Saxkoebing and Grippotyphosa. In comparison with previous periods, the mean yearly number of patients with leptospirosis hospitalised at UHID decreased, but among them a rather higher rate of patients with Weil's disease and a higher CFR was observed.
本研究从流行病学和临床角度呈现了克罗地亚人类钩端螺旋体病的现状。本回顾性队列分析使用了克罗地亚公共卫生研究所年度报告的数据以及萨格勒布传染病大学医院（UHID）的档案。1990 年至 2007 年期间，钩端螺旋体病的年平均发病率为 1.83/100000 居民，发病率>2.5/100000 居民约每 3-4 年记录一次，使克罗地亚成为欧洲发病率最高的国家之一。除了大多数散发病例外，还记录了两起小暴发。还研究了 1997-2007 年期间在 UHID 住院的 130 名患者的临床负担和更详细的流行病学。临床表现如预期的那样，总病死率（CFR）为 0.77%。最常见的确定感染血清型是 Australis，其次是 Saxkoebing 和 Grippotyphosa。与前一时期相比，UHID 住院的钩端螺旋体病患者的年平均数量有所减少，但其中 Weil 病患者的比例较高，CFR 也较高。
